Franzén L, Sundström S, Karlsson M, Gustafsson H, Littbrand B, Henriksson R
Department of Oncology, University Hospital, Umeå, Sweden.
Acta Oncol. 1992;31(3):359-64. doi: 10.3109/02841869209108186.
The effects of fractionated irradiation on the electrolyte fluid secretion from rat parotid gland were studied. Secretion was measured as noradrenaline stimulated potassium efflux in vitro with 86Rb+ as tracer for potassium. The irradiation was delivered either as a five-day schedule (total dose 20, 25, 30, 35, 40, 45 Gy) or a two-day schedule (total dose 24, 32 Gy). The noradrenaline stimulated efflux was decreased in comparison with contralateral controls 10 days after the last irradiation. The effect was dose-dependent. Based on the data available, alpha/beta ratio of the used system was calculated to about 20 Gy, which corresponds to other results regarding early radiation effects.
研究了分次照射对大鼠腮腺电解质分泌的影响。以去甲肾上腺素刺激的钾外流作为分泌指标，在体外以⁸⁶Rb⁺作为钾的示踪剂进行测量。照射采用五天方案（总剂量20、25、30、35、40、45 Gy）或两天方案（总剂量24、32 Gy）。在最后一次照射后10天，与对侧对照相比，去甲肾上腺素刺激的外流减少。该效应呈剂量依赖性。根据现有数据，所用系统的α/β比值计算约为20 Gy，这与早期辐射效应的其他结果相符。
