Gustafsson H, Franzén L, Sundström S, Henriksson R
Department of Otorhinolaryngology, University Hospital, Umeå, Sweden.
Acta Otolaryngol Suppl. 1992;492:94-8. doi: 10.3109/00016489209136820.
Irradiation of head-neck cancer influences the salivary glands with dryness and discomfort for the patients as a consequence. In the present study we used in vitro secretory models and morphological characterization of rat parotid gland. Irradiation was given as a 5-day schedule with total doses from 20 Gy to 45 Gy. Electrolyte secretion (86Rb as indicator for potassium) caused by noradrenaline was decreased in correlation to irradiation dose delivered compared to controlateral control glands 10 days following irradiation. Noradrenaline stimulated exocytotic amylase release was not at all affected, and there were no signs of quantitative morphological alterations following irradiation compared to control glands. The results indicate that there are differences in radiation sensitivity for the two different secretory processes in the salivary glands; the structures regulating electrolyte and fluid secretion seem to be more vulnerable to irradiation than those regulating exocytosis.
头颈癌放疗会影响唾液腺，导致患者出现口干和不适。在本研究中，我们使用了大鼠腮腺的体外分泌模型和形态学特征。放疗采用为期5天的方案，总剂量为20 Gy至45 Gy。与照射后10天的对侧对照腺体相比，去甲肾上腺素引起的电解质分泌（以86Rb作为钾的指示剂）与所给予的照射剂量相关而降低。去甲肾上腺素刺激的淀粉酶胞吐释放完全未受影响，与对照腺体相比，照射后没有定量形态学改变的迹象。结果表明，唾液腺中两种不同分泌过程的辐射敏感性存在差异；调节电解质和液体分泌的结构似乎比调节胞吐作用的结构更容易受到辐射影响。
