Ambani Dipika S, White Beverly, Kaplan Alan L, Alberto Ayala
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA.
Gynecol Oncol. 2006 Feb;100(2):433-6. doi: 10.1016/j.ygyno.2005.09.013. Epub 2005 Oct 14.
Synovial sarcoma is the fourth most commonly occurring sarcoma, accounting for 8-10% of all sarcomas. They arise from unknown pleuripotent stem cells that are capable of differentiating into mesenchymal and/or epithelial structures. Synovial sarcoma is characterized by specific chromosomal translocation t (X; 18)(p11, q11).
We report the first case of monophasic synovial sarcoma arising in soft tissues of the vulva in a 33-year-old female. Complete excision of the mass was possible with tumor-free margins.
Only four previous cases of biphasic synovial sarcoma arising in the vulva have been reported. The finding of the SYT-SSX2 translocation is generally associated with a better prognosis, besides tumor negative margins after excision offer the possibility of a better outlook for this patient.
滑膜肉瘤是第四常见的肉瘤，占所有肉瘤的8 - 10%。它们起源于未知的多能干细胞，这些干细胞能够分化为间充质和/或上皮结构。滑膜肉瘤的特征是特定的染色体易位t(X;18)(p11,q11)。
我们报告了首例发生于一名33岁女性外阴软组织的单相滑膜肉瘤病例。肿块得以完整切除，切缘无肿瘤残留。
此前仅报道过4例发生于外阴的双相滑膜肉瘤病例。SYT - SSX2易位的发现通常与较好的预后相关，此外，切除术后切缘无肿瘤残留为该患者带来了更好的前景。
