一例表现为外阴肿块的单相滑膜肉瘤病例。
A case of monophasic synovial sarcoma presenting as a vulvar mass.
作者信息
Ambani Dipika S, White Beverly, Kaplan Alan L, Alberto Ayala
机构信息
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Gynecol Oncol. 2006 Feb;100(2):433-6. doi: 10.1016/j.ygyno.2005.09.013. Epub 2005 Oct 14.
BACKGROUND
Synovial sarcoma is the fourth most commonly occurring sarcoma, accounting for 8-10% of all sarcomas. They arise from unknown pleuripotent stem cells that are capable of differentiating into mesenchymal and/or epithelial structures. Synovial sarcoma is characterized by specific chromosomal translocation t (X; 18)(p11, q11).
CASE
We report the first case of monophasic synovial sarcoma arising in soft tissues of the vulva in a 33-year-old female. Complete excision of the mass was possible with tumor-free margins.
CONCLUSION
Only four previous cases of biphasic synovial sarcoma arising in the vulva have been reported. The finding of the SYT-SSX2 translocation is generally associated with a better prognosis, besides tumor negative margins after excision offer the possibility of a better outlook for this patient.
背景
滑膜肉瘤是第四常见的肉瘤，占所有肉瘤的8 - 10%。它们起源于未知的多能干细胞，这些干细胞能够分化为间充质和/或上皮结构。滑膜肉瘤的特征是特定的染色体易位t(X;18)(p11,q11)。
病例
我们报告了首例发生于一名33岁女性外阴软组织的单相滑膜肉瘤病例。肿块得以完整切除，切缘无肿瘤残留。
结论
此前仅报道过4例发生于外阴的双相滑膜肉瘤病例。SYT - SSX2易位的发现通常与较好的预后相关，此外，切除术后切缘无肿瘤残留为该患者带来了更好的前景。
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