Department of Pathology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Studničkova 2, Prague 2, 12800, Czech Republic.
Pathol Oncol Res. 2012 Apr;18(2):529-33. doi: 10.1007/s12253-011-9391-x. Epub 2011 Apr 14.
We report a case of a 52-year-old female with synovial sarcoma of the uterine corpus. Grossly, the partly polypoid tumor involved the endometrium with invasion into the inner half of the myometrium. Histologically, the tumor showed biphasic structure with the predominance of poorly differentiated small to medium sized round to oval cells. These cells showed high nuclear to cytoplasmic ratio and were arranged in diffuse sheets. Other component consisted of larger epitheloid cells with ample eosinophilic cytoplasm arranged in irregular nests. These cells were only present in a small amount. Immunohistochemically, the tumor cells in both components showed the expression of EMA, S-100 protein, CD99, and NSE. RT-PCR analysis showed the presence of SYT-SSX1 fusion transcript. At present, the patient shows no signs of tumor relapse 56 months after the diagnosis. To the best of our knowledge, this is the first report of synovial sarcoma arising in uterus.
我们报告一例 52 岁女性的子宫滑膜肉瘤。大体上，部分息肉状肿瘤累及子宫内膜并侵犯子宫肌层的内半部分。组织学上，肿瘤呈双相结构，以分化不良的中小圆形至椭圆形细胞为主。这些细胞具有高核浆比，呈弥漫片状排列。另一个组成部分由具有丰富嗜酸性细胞质的较大上皮样细胞组成，呈不规则巢状排列。这些细胞仅存在少量。免疫组织化学染色显示，两个成分中的肿瘤细胞均表达 EMA、S-100 蛋白、CD99 和 NSE。RT-PCR 分析显示存在 SYT-SSX1 融合转录本。目前，该患者在诊断后 56 个月尚无肿瘤复发迹象。据我们所知，这是首例发生于子宫的滑膜肉瘤。
