Yoon Jong H, Curtis Clayton E, D'Esposito Mark
Henry H. Wheeler Jr. Brain Imaging Center, 132 Barker Hall, University of California Berkeley, Berkeley, CA 94720-1650, USA.
Neuroimage. 2006 Feb 15;29(4):1117-26. doi: 10.1016/j.neuroimage.2005.08.024. Epub 2005 Oct 14.
Maintaining relevant information for later use is a critical aspect of working memory (WM). The lateral prefrontal cortex (PFC) and posterior sensory cortical areas appear to be important in supporting maintenance. However, the relative and unique contributions of these areas remain unclear. We have designed a WM paradigm with distraction to probe the contents of maintenance representations in these regions. During delayed recognition trials of faces, selective interference was evident behaviorally with face distraction leading to significantly worse performance than with scene distraction. Event-related fMRI of the human brain showed that maintenance activity in the lateral PFC, but not in visual association cortex (VAC), was selectively disrupted by face distraction. Additionally, the functional connectivity between the lateral PFC and the VAC was perturbed during these trials. We propose a hierarchical and distributed model of active maintenance in which the lateral PFC codes for abstracted mnemonic information, while sensory areas represent specific features of the memoranda. Furthermore, persistent coactivation between the PFC and sensory areas may be a mechanism by which information is actively maintained.
保留相关信息以供后续使用是工作记忆（WM）的一个关键方面。外侧前额叶皮层（PFC）和后部感觉皮层区域在支持信息保留方面似乎很重要。然而，这些区域的相对和独特贡献仍不清楚。我们设计了一种带有干扰的工作记忆范式，以探究这些区域中维持表征的内容。在面孔的延迟识别试验中，行为上的选择性干扰很明显，面孔干扰导致的表现明显比场景干扰更差。对人脑进行的事件相关功能磁共振成像显示，外侧PFC的维持活动，而非视觉联合皮层（VAC）的维持活动，被面孔干扰选择性地破坏。此外，在这些试验中，外侧PFC与VAC之间的功能连接受到干扰。我们提出了一种主动维持的分层分布式模型，其中外侧PFC编码抽象的记忆信息，而感觉区域则表征记忆内容的特定特征。此外，PFC与感觉区域之间的持续共同激活可能是信息被主动维持的一种机制。
