• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

工作记忆期间的干扰项预期与跨空间尺度的θ波和β波振荡有关。

Distractor anticipation during working memory is associated with theta and beta oscillations across spatial scales.

作者信息

Jung Dennis Y, Sahoo Bikash C, Snyder Adam C

机构信息

Neuroscience Graduate Program, University of Rochester, Rochester, NY, United States.

Center for Visual Science, University of Rochester, Rochester, NY, United States.

出版信息

Front Integr Neurosci. 2025 Mar 24;19:1553521. doi: 10.3389/fnint.2025.1553521. eCollection 2025.

DOI:10.3389/fnint.2025.1553521
PMID:40196759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11973340/
Abstract

INTRODUCTION

Anticipating distractors during working memory maintenance is critical to reduce their disruptive effects. In this study, we aimed to identify the oscillatory correlates of this process across different spatial scales of neural activity.

METHODS

We simultaneously recorded local field potentials (LFP) from the lateral prefrontal cortex (LPFC) and electroencephalograms (EEG) from the scalp of monkeys performing a modified memory-guided saccade (MGS) task. The monkeys were required to remember the location of a target visual stimulus while anticipating distracting visual stimulus, flashed at 50% probability during the delay period.

RESULTS

We found significant theta-band activity across spatial scales during anticipation of a distractor, closely linked with underlying working memory dynamics, through decoding and cross-temporal generalization analyses. EEG particularly reflected reactivation of memory around the anticipated time of a distractor, even in the absence of stimuli. During this anticipated time, beta-band activity exhibited transiently enhanced intrahemispheric communication between the LPFC and occipitoparietal brain areas. These oscillatory phenomena were observed only when the monkeys successfully performed the task, implicating their possible functional role in mitigating anticipated distractors.

DISCUSSION

Our results demonstrate that distractor anticipation recruits multiple oscillatory processes across the brain during working memory maintenance, with a key activity observed predominantly in the theta and beta bands.

摘要

引言

在工作记忆维持过程中预测干扰物对于减少其干扰作用至关重要。在本研究中，我们旨在确定这一过程在不同神经活动空间尺度上的振荡相关性。

方法

我们同时记录了执行改良记忆引导扫视（MGS）任务的猴子外侧前额叶皮层（LPFC）的局部场电位（LFP）和头皮脑电图（EEG）。猴子需要记住目标视觉刺激的位置，同时预测延迟期内以50%概率闪现的干扰视觉刺激。

结果

通过解码和跨时间泛化分析，我们发现在预测干扰物期间，跨空间尺度存在显著的θ波段活动，这与潜在的工作记忆动态密切相关。EEG尤其反映了在预测干扰物出现时间前后记忆的重新激活，即使在没有刺激的情况下也是如此。在这个预测时间内，β波段活动表现出LPFC与枕顶脑区之间半球内通信的短暂增强。这些振荡现象仅在猴子成功执行任务时观察到，暗示了它们在减轻预期干扰物方面可能的功能作用。

讨论

我们的结果表明，在工作记忆维持过程中，预测干扰物会在大脑中引发多个振荡过程，主要在θ和β波段观察到关键活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/f0e0d59f44f4/fnint-19-1553521-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/35df31a91107/fnint-19-1553521-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/25d58ab37a6e/fnint-19-1553521-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/bf3e1b2d52f1/fnint-19-1553521-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/f6b038d841cd/fnint-19-1553521-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/45d8e7279fe4/fnint-19-1553521-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/8816a2047a52/fnint-19-1553521-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/bf9328a34652/fnint-19-1553521-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/ce4ba07223eb/fnint-19-1553521-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/bc47dae65b93/fnint-19-1553521-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/9d5a8462c17a/fnint-19-1553521-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/9a64de0ce071/fnint-19-1553521-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/f0e0d59f44f4/fnint-19-1553521-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/35df31a91107/fnint-19-1553521-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/25d58ab37a6e/fnint-19-1553521-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/bf3e1b2d52f1/fnint-19-1553521-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/f6b038d841cd/fnint-19-1553521-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/45d8e7279fe4/fnint-19-1553521-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/8816a2047a52/fnint-19-1553521-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/bf9328a34652/fnint-19-1553521-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/ce4ba07223eb/fnint-19-1553521-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/bc47dae65b93/fnint-19-1553521-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/9d5a8462c17a/fnint-19-1553521-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/9a64de0ce071/fnint-19-1553521-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac02/11973340/f0e0d59f44f4/fnint-19-1553521-g0012.jpg

相似文献

1
Distractor anticipation during working memory is associated with theta and beta oscillations across spatial scales.工作记忆期间的干扰项预期与跨空间尺度的θ波和β波振荡有关。
Front Integr Neurosci. 2025 Mar 24;19:1553521. doi: 10.3389/fnint.2025.1553521. eCollection 2025.
2
Short-Term Memory Impairment短期记忆障碍
3
Modulation of Cerebellar Oscillations with Subthalamic Stimulation in Patients with Parkinson's Disease.小脑刺激对帕金森病患者的调节。
J Parkinsons Dis. 2024;14(7):1417-1426. doi: 10.3233/JPD-240065.
4
Distinct age-related alterations in alpha-beta neural oscillatory activity during verbal working memory encoding in children and adolescents.儿童和青少年在言语工作记忆编码过程中，α-β神经振荡活动存在与年龄相关的明显变化。
J Physiol. 2025 Apr;603(8):2387-2408. doi: 10.1113/JP287372. Epub 2025 Mar 7.
5
Feedback scales the spatial tuning of cortical responses during both visual working memory and long-term memory.反馈在视觉工作记忆和长期记忆过程中调节皮层反应的空间调谐。
J Neurosci. 2025 Mar 14;45(17). doi: 10.1523/JNEUROSCI.0681-24.2025.
6
The primate cortical LFP exhibits multiple spectral and temporal gradients and widespread task dependence during visual short-term memory.灵长类动物皮层 LFPs 在视觉短期记忆过程中表现出多种频谱和时频梯度以及广泛的任务相关性。
J Neurophysiol. 2024 Jul 1;132(1):206-225. doi: 10.1152/jn.00264.2023. Epub 2024 Jun 6.
7
Dynamic Modulation of Beta-Band Oscillations in the LGN and Their Role in Visual Processing.外侧膝状体中β波段振荡的动态调制及其在视觉处理中的作用。
bioRxiv. 2025 Jul 13:2025.07.08.663741. doi: 10.1101/2025.07.08.663741.
8
Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex.操控注意力优先级会在人类视觉皮层的记忆与感觉表征之间形成一种权衡。
bioRxiv. 2024 Sep 16:2024.09.16.613302. doi: 10.1101/2024.09.16.613302.
9
Growing together: Dynamic connectivity between developmentally sensitive regions serving verbal working memory in children and adolescents.共同成长：儿童和青少年中服务于言语工作记忆的发育敏感区域之间的动态连接
J Physiol. 2025 May;603(10):3107-3121. doi: 10.1113/JP287721. Epub 2025 May 5.
10
Methylphenidate, Guanfacine, and Combined Treatment Effects on Electroencephalography Correlates of Spatial Working Memory in Attention-Deficit/Hyperactivity Disorder.哌甲酯、胍法辛及联合治疗对注意缺陷多动障碍患者空间工作记忆的脑电图相关性的影响。
J Am Acad Child Adolesc Psychiatry. 2023 Jan;62(1):37-47. doi: 10.1016/j.jaac.2022.06.017. Epub 2022 Aug 10.

本文引用的文献

1
The strength of anticipated distractors shapes EEG alpha and theta oscillations in a Working Memory task.预期干扰物的强度会影响工作记忆任务中的 EEGα 和θ 脑波震荡。
Neuroimage. 2024 Oct 15;300:120835. doi: 10.1016/j.neuroimage.2024.120835. Epub 2024 Sep 7.
2
Beta: bursts of cognition.贝塔：认知爆发。
Trends Cogn Sci. 2024 Jul;28(7):662-676. doi: 10.1016/j.tics.2024.03.010. Epub 2024 Apr 23.
3
A ubiquitous spectrolaminar motif of local field potential power across the primate cortex.普遍存在于灵长类皮层局部场电位功率中的spectrolaminar 基序。
Nat Neurosci. 2024 Mar;27(3):547-560. doi: 10.1038/s41593-023-01554-7. Epub 2024 Jan 18.
4
Dissociable neuronal substrates of visual feature attention and working memory.视觉特征注意和工作记忆的可分离神经元基质。
Neuron. 2024 Mar 6;112(5):850-863.e6. doi: 10.1016/j.neuron.2023.12.007. Epub 2024 Jan 15.
5
Attention in flux.注意力转移。
Neuron. 2023 Apr 5;111(7):971-986. doi: 10.1016/j.neuron.2023.02.032.
6
Greater variability in rhesus macaque () endocranial volume among males than females.雄性恒河猴的脑内（）容积的变异性大于雌性。
Proc Biol Sci. 2022 Nov 9;289(1986):20220728. doi: 10.1098/rspb.2022.0728.
7
Alpha oscillations reflect suppression of distractors with increased perceptual load.阿尔法振荡反映了在感知负荷增加时对干扰物的抑制。
Prog Neurobiol. 2022 Jul;214:102285. doi: 10.1016/j.pneurobio.2022.102285. Epub 2022 May 6.
8
Interhemispheric Connectivity Supports Load-Dependent Working Memory Maintenance for Complex Visual Stimuli.大脑两半球间的连接支持复杂视觉刺激的负载依赖工作记忆维持。
Brain Connect. 2022 Dec;12(10):892-904. doi: 10.1089/brain.2021.0171. Epub 2022 Jun 1.
9
Mechanisms of distributed working memory in a large-scale network of macaque neocortex.猴新大脑皮层大规模网络中分布式工作记忆的机制。
Elife. 2022 Feb 24;11:e72136. doi: 10.7554/eLife.72136.
10
Modulating verbal working memory with fronto-parietal transcranial electric stimulation at theta frequency: Does it work?经颅交流电刺激 theta 频段调节额顶叶言语工作记忆：有效吗？
Eur J Neurosci. 2022 Jan;55(2):405-425. doi: 10.1111/ejn.15563. Epub 2022 Jan 11.