Nishimura Youichi, Kitoh Akihiko, Yoshida Yoko, Tanaka Toshihiro
Department of Dermatology, Tenri Yorozu Hospital, Nara, Japan.
J Am Acad Dermatol. 2005 Nov;53(5 Suppl 1):S231-3. doi: 10.1016/j.jaad.2005.03.003.
Drug-induced hypersensitivity syndrome is a severe drug eruption with fatal visceral organ failures associated with human herpesvirus-6 (HHV-6) reactivation. We present a case of clomipramine-induced hypersensitivity syndrome, which displayed in succession two different reactions akin to those described for Gianotti-Crosti syndrome and infectious mononucleosis. HHV-6 reactivation was confirmed serologically after the latter reaction, suggesting that our case may have represented a biphasic reaction to HHV-6 reactivation.
药物性超敏反应综合征是一种严重的药疹，伴有与人类疱疹病毒6型（HHV-6）再激活相关的致命性内脏器官衰竭。我们报告一例氯米帕明诱发的超敏反应综合征，该病例先后出现了两种类似于Gianotti-Crosti综合征和传染性单核细胞增多症所描述的不同反应。在后一种反应后通过血清学证实了HHV-6再激活，提示我们的病例可能代表了对HHV-6再激活的双相反应。
