与氯米帕明诱导的间质性肾炎相关的可逆性急性肾衰竭。

Reversible acute renal failure associated with clomipramine-induced interstitial nephritis.

作者信息

Onishi Akira, Yamamoto Hisashi, Akimoto Tetsu, Saito Osamu, Inoue Makoto, Ando Yasuhiro, Muto Shigeaki, Kusano Eiji

机构信息

Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.

出版信息

Clin Exp Nephrol. 2007 Sep;11(3):241-243. doi: 10.1007/s10157-007-0485-4. Epub 2007 Sep 28.

DOI:10.1007/s10157-007-0485-4

PMID:17891354

Abstract

We describe a 41-year old man with obsessive-compulsive neurosis who developed acute renal failure (ARF) due to acute interstitial nephritis (AIN) during 6 weeks of treatment with clomipramine hydrochloride (CPH). He had a slight fever, mild arthralgia, appetite loss, and diarrhea after taking CPH. On admission, he showed serum creatinine (sCr) of 7.31 mg/dl, and creatinine clearance (Ccr) of 2.5 ml/min. He subsequently became anuric and required hemodialysis. Renal biopsy revealed AIN with diffuse mononuclear cell infiltration. After the withdrawal of CPH and treatment with prednisolone (PSL) 0.5 mg/kg per day, his urinary output improved, along with improvement of his renal function; therefore hemodialysis was finally discontinued. To our knowledge, this is the first case report of AIN induced by clomipramine.

摘要

我们描述了一名患有强迫性神经症的41岁男性，他在接受盐酸氯米帕明（CPH）治疗6周期间因急性间质性肾炎（AIN）而发生急性肾衰竭（ARF）。服用CPH后，他出现低热、轻度关节痛、食欲减退和腹泻。入院时，他的血清肌酐（sCr）为7.31mg/dl，肌酐清除率（Ccr）为2.5ml/min。随后他出现无尿，需要进行血液透析。肾活检显示AIN伴弥漫性单核细胞浸润。停用CPH并每天使用0.5mg/kg泼尼松龙（PSL）治疗后，他的尿量增加，肾功能也有所改善；因此最终停止了血液透析。据我们所知，这是首例由氯米帕明引起的AIN病例报告。