Ihara Nobumaro, Shibuya Hitoshi, Yoshimura Ryoichi, Oota Sayako, Miura Masahiko, Watanabe Hiroshi
Department of Radiology, Graduate School, Tokyo Medical and Dental University, 5-45 Yushima 1-Chome, Bunkyo-ku, Tokyo 113-8519, Japan.
Acta Oncol. 2005;44(7):709-16. doi: 10.1080/02841860500267881.
The purpose of this study is to describe the cause-specific survival rate, local control rate, salvage rate of neck metastasis, and post-treatment eating and speaking conditions for stage III mobile tongue squamous cell carcinomas and its subgroups. Between 1968 and 1999, 117 previously untreated patients with stage III mobile tongue carcinomas underwent mainly brachytherapy with external beam irradiation (EBRT) and neck dissection. A multivariate analysis was performed for the cause-specific survival rate on the various factors. The 1-, 3- and 5-year cause-specific survival rates for all patients were 76%, 54% and 54%, respectively. The 1-, 3- and 5-year primary control rates for all patients were 67.6%, 63.4% and 59.2%, respectively. There were statistically significant differences in cause-specific survival rates among stage III subgroups of T3N0, T1-2N1 and T3N1 (p = 0.0002). Our treatment method for patients with stage III mobile tongue squamous cell carcinoma was effective and acceptable.
本研究旨在描述Ⅲ期可活动舌鳞状细胞癌及其亚组的病因特异性生存率、局部控制率、颈部转移挽救率以及治疗后的进食和说话情况。1968年至1999年间，117例未经治疗的Ⅲ期可活动舌癌患者主要接受了近距离放疗、外照射放疗（EBRT）和颈部清扫术。对各种因素的病因特异性生存率进行了多因素分析。所有患者的1年、3年和5年病因特异性生存率分别为76%、54%和54%。所有患者的1年、3年和5年原发灶控制率分别为67.6%、63.4%和59.2%。T3N0、T1-2N1和T3N1的Ⅲ期亚组之间病因特异性生存率存在统计学显著差异（p = 0.0002）。我们对Ⅲ期可活动舌鳞状细胞癌患者的治疗方法是有效且可接受的。
