Colosimo C, Pantano P, Calistri V, Totaro P, Fabbrini G, Berardelli A
Department of Neurological Sciences, University La Sapienza, I-00185 Rome, Italy.
J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1591-3. doi: 10.1136/jnnp.2004.056614.
It is the traditional view that primary dystonia arises from abnormal basal ganglia function but causes no apparent morphological changes.
To determine whether cervical dystonia leads to ultrastructural changes in the brain, using diffusion tensor imaging to compare brain structure in 15 patients with cervical dystonia with 10 healthy controls.
Fractional anisotropy (FA) and mean diffusivity (MD) were obtained in 17 brain regions of interest.
Patients had higher FA values than controls in both putamina and lower FA values in the genu and in the body of the corpus callosum. Patients also had lower MD values in the left pallidum, the left putamen, and both caudati.
In patients with cervical dystonia, diffusion tensor imaging shows ultrastructural changes in specific brain areas, including the basal ganglia.
传统观点认为原发性肌张力障碍源于基底神经节功能异常，但无明显形态学改变。
利用扩散张量成像比较15例颈部肌张力障碍患者与10名健康对照者的脑结构，以确定颈部肌张力障碍是否会导致脑超微结构改变。
在17个感兴趣脑区获取分数各向异性（FA）和平均扩散率（MD）。
患者双侧壳核的FA值高于对照组，胼胝体膝部和体部的FA值低于对照组。患者左侧苍白球、左侧壳核和双侧尾状核的MD值也较低。
在颈部肌张力障碍患者中，扩散张量成像显示特定脑区（包括基底神经节）存在超微结构改变。
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