Bilska Anna, Włodek Lidia
Institute of Medical Biochemistry, Medical College, Jagiellonian University, Kopernika 7, PL 31-034 Kraków, Poland.
Pharmacol Rep. 2005 Sep-Oct;57(5):570-7.
Numerous experimental and clinical studies proved efficiency of treatment with lipoic acid-containing drugs in diseases, in which pro- and antioxidant balance is disrupted (diabetes, neurodegenerative diseases, acquired immune deficiency syndrome (AIDS), tumors, etc.). Efficiency of lipoate has been attributed to unique antioxidant properties of lipoate/dihydrolipoate system, its reactive oxygen species (ROS) scavenging ability and significant effect on the tissue concentrations of reduced forms of other antioxidants, including one of the most powerful, glutathione (thus lipoate is called an antioxidant of antioxidants). Moreover, analysis of literature data suggests participation of lipoic acid in processes of cell growth and differentiation. This fact can be crucial to clinical practice, however, this problem requires further studies.
大量实验和临床研究证明，含硫辛酸的药物在疾病治疗中具有有效性，这些疾病包括体内促氧化剂和抗氧化剂平衡被破坏的情况（糖尿病、神经退行性疾病、获得性免疫缺陷综合征（艾滋病）、肿瘤等）。硫辛酸酯的有效性归因于硫辛酸酯/二氢硫辛酸酯系统独特的抗氧化特性、其清除活性氧（ROS）的能力以及对其他抗氧化剂还原形式的组织浓度有显著影响，其中包括最强大的抗氧化剂之一谷胱甘肽（因此硫辛酸被称为抗氧化剂的抗氧化剂）。此外，对文献数据的分析表明硫辛酸参与细胞生长和分化过程。这一事实对临床实践可能至关重要，然而，这个问题需要进一步研究。
