Tamagawa Hiroshi, Yoneyama Katuya, Sugano Nobuhiro, Jin Yasuyuki, Kasahara Akio, Yamamoto Yuji, Takanashi Yoshinori, Rino Yasushi
Dept. of Surgery, Kanagawa Prefectural Asigarakami Hospital.
Gan To Kagaku Ryoho. 2005 Oct;32(10):1443-5.
A patient was a 66-year-old male who had advanced gastric cancer with left gastric artery lymph node metastasis and invasion of pancreas and spleen. We thought a complete resection was difficult, so he was given neo-adjuvant chemotherapy by combined of TS-1 100 mg/day (2 weeks administration and 1 week rest) and Paclitaxel (PTX) 75 mg/body (day 1, 8). After 2 courses of this neo-adjuvant chemotherapy, tumor and lymph node swelling had decreased in size, and the tumor markers were reduced remarkably (CEA 9 2.5 --> 12.2 ng/ml, CA 19-9 2, 739 --> 19 3 U/ml). He underwent total gastrectomy and Roux-en Y reconstruction. No.4 d and No.7 lymph nodes were swollen and hard, but white with a neurotic-like appearance. On pathological study, no malignancy was seen in the lymph nodes, and a good partial response was achieved. In this chemotherapy, no side effects were seen, and he maintained good quality of life. TS-1/PTX therapy was thought to be an effective neoadjuvant chemotherapy for advanced gastric cancer.
一名66岁男性患者，患有晚期胃癌，伴有胃左动脉淋巴结转移以及胰腺和脾脏侵犯。我们认为完整切除困难，因此给予他新辅助化疗，方案为TS-1 100毫克/天（给药2周，休息1周）联合紫杉醇（PTX）75毫克/人（第1天、第8天）。经过2个疗程的新辅助化疗后，肿瘤和淋巴结肿大尺寸减小，肿瘤标志物显著降低（癌胚抗原92.5 --> 12.2纳克/毫升，糖类抗原19-9 2739 --> 193单位/毫升）。他接受了全胃切除术和Roux-en-Y重建术。第4组和第7组淋巴结肿大且硬，但呈白色，外观类似神经样。病理研究显示，淋巴结未见恶性肿瘤，达到了良好的部分缓解。在此次化疗中，未见副作用，他维持了良好的生活质量。TS-1/PTX疗法被认为是晚期胃癌有效的新辅助化疗方法。
