Naito Haruhiko, Hamada Tomonori, Shinohara Toshiki, Mino Kazuhiro, Shibazaki Wataru, Minagawa Nozomi, Orimo Tatsuya, Ichimura Wataru
Dept. of Surgery, National Hospital Organization, Hokkaido Cancer Center.
Gan To Kagaku Ryoho. 2005 Oct;32(10):1469-72.
A sixty-eight-year-old man was operated on for Stage IV gastric cancer with total gastrectomy and D3 lymph node dissection. The right gastric artery was filled with tumor thrombosis, but tumor tissue was left on the cut stump. Intraoperative ultrasonic liver scanning revealed the suspected metastatic images. Mitomycin C 20 mg dissolved in glue was then pasted at the artery cut stump. Although intraarterial infusion of adriamycin 20 mg, systemic methotrexate + 5-FU alternative therapy and daily medication of UFT-E 400 mg were administered, liver metastasis developed in follow-up CT scans 6 months later. Since 9 months after operation,continuous intraarterial infusion of 5-FU 250 mg/24 hours for 7 days was given biweekly, and was repeated 44 times for the next 27 months. This chemotherapeutic modality purged the liver metastasis. The patient has now survived 7 years 3 months with no therapy.
一名68岁男性因IV期胃癌接受了全胃切除术及D3淋巴结清扫术。胃右动脉充满肿瘤血栓，但在切除残端残留有肿瘤组织。术中肝脏超声扫描显示有疑似转移灶影像。随后将溶解于胶水的20毫克丝裂霉素C粘贴于动脉切除残端。尽管进行了20毫克阿霉素动脉内输注、全身甲氨蝶呤+5-氟尿嘧啶交替治疗以及每日服用400毫克优福定，但6个月后的随访CT扫描显示出现了肝转移。自术后9个月起，每两周进行一次为期7天的持续动脉内输注250毫克/24小时的5-氟尿嘧啶，在接下来的27个月里重复了44次。这种化疗方式清除了肝转移灶。该患者目前未经治疗已存活7年3个月。
