Usui Tomohiko, Sugisaki Kenji, Amano Shiro, Jang Woo-Dong, Nishiyama Nobuhiro, Kataoka Kazunori
Department of Ophthalmology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Cornea. 2005 Nov;24(8 Suppl):S39-S42. doi: 10.1097/01.ico.0000178738.29459.59.
To introduce photodynamic therapy (PDT) for corneal neovascularization (NV) by polyion complex (PIC) micelles, a novel drug delivery system.
Development of specific drug delivery systems to corneal NV sites is an important part of next-generation photodynamic therapy. Nanocarriers consisting of PIC micelles bound by polyethylene glycol (PEG) shell exhibit good stability, high drug-loading capacity, and excellent potential for controlled drug release. Encapsulation of the photosensitizer dendrimer porphyrin (DP) into PIC micelles (DP-micelles) conveys adequate stability and increased photocytotoxicity without compromising photophysical properties of DP stability. We assessed the accumulation of DP-micelles and observed that the DP-micelles were incorporated into the corneal NV area.
PIC micelles possess attractive features of selective accumulation at the corneal NV site. PDT using DP-micelles appears to be effective and safe for the treatment of corneal NV.
介绍一种新型药物递送系统——聚离子复合物（PIC）胶束用于角膜新生血管（NV）的光动力疗法（PDT）。
开发针对角膜NV部位的特异性药物递送系统是下一代光动力疗法的重要组成部分。由聚乙二醇（PEG）外壳包裹的PIC胶束组成的纳米载体具有良好的稳定性、高载药量以及出色的可控药物释放潜力。将光敏剂树枝状卟啉（DP）封装到PIC胶束（DP-胶束）中可提供足够的稳定性并增强光细胞毒性，同时不影响DP稳定性的光物理性质。我们评估了DP-胶束的蓄积情况，并观察到DP-胶束被纳入角膜NV区域。
PIC胶束具有在角膜NV部位选择性蓄积的诱人特性。使用DP-胶束的PDT似乎对治疗角膜NV有效且安全。
