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玻璃体内注射曲安奈德后结膜坏死

Conjunctival necrosis following intravitreal injection of triamcinolone acetonide.

作者信息

Srinivasan Sathish, Prasad Somdutt

机构信息

Department of Ophthalmology, Arrowe Park Hospital, Wirral, UK.

出版信息

Cornea. 2005 Nov;24(8):1027-8. doi: 10.1097/01.ico.0000159754.05736.8c.

Abstract

PURPOSE

To report a case of localized conjunctival necrosis following intravitreal injection of triamcinolone acetonide (TA).

DESIGN

Single observational case report.

METHODS

A 63-year- old man presented with inferotemporal branch retinal vein occlusion and macular edema in his left eye (OS). He underwent pars plana vitrectomy combined with arteriovenous sheathotomy. Postoperatively, as the macular edema persisted, he underwent an uneventful intravitreal injection of TA.

RESULTS

Ten days following the intravitreal injection, he presented with an area of localized conjunctival necrosis overlying the scleral entry site. Gram stain showed a few white blood cells and no organisms. The conjunctival swab showed no growth on culture. The area of conjunctival necrosis responded well to intense topical antibiotic therapy.

CONCLUSIONS

Conjunctival necrosis is a rare anterior segment complication of intravitreal injection of TA. With the increased usage of intravitreal TA for various posterior segment disorders, the treating physician should be aware of this complication.

摘要

目的

报告1例玻璃体内注射曲安奈德(TA)后发生局限性结膜坏死的病例。

设计

单例观察性病例报告。

方法

一名63岁男性,左眼(OS)出现颞下分支视网膜静脉阻塞和黄斑水肿。他接受了玻璃体切除术联合动静脉鞘膜切开术。术后,由于黄斑水肿持续存在,他顺利接受了玻璃体内TA注射。

结果

玻璃体内注射后10天,他在巩膜穿刺部位上方出现局限性结膜坏死区域。革兰氏染色显示有少量白细胞,未发现微生物。结膜拭子培养无生长。结膜坏死区域对强化局部抗生素治疗反应良好。

结论

结膜坏死是玻璃体内注射TA罕见的前段并发症。随着玻璃体内TA在各种后段疾病中的使用增加,治疗医生应意识到这种并发症。

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