Moriya Takuya, Mikami Yoshiki, Sakamoto Kazuhiro, Endoh Mareyuki, Takeyama Junji, Suzuki Takashi, Mochizuki Shizue, Watanabe Mika, Monobe Yasumasa, Sasano Hironobu
Department of Pathology, Tohoku University Hospital, Aoba-ku, Sendai 980-8574, Japan.
Med Electron Microsc. 2003 Dec;36(4):240-6. doi: 10.1007/s00795-003-0221-4.
Endocervical-like mucinous borderline tumor (EMBT) is a distinct entity of the ovary that seems to be underrecognized. It occurs with relatively high frequency in Japanese women. Compared with intestinal-type mucinous borderline tumor (IMBT), more frequent bilateral occurrence, paucilocular cysts, association with endometriosis, absence of pseudomyxoma but possible association of peritoneal implants and lymph node metastases, and lower mortality rate are the characteristic features. Histologically, it consists of a mixture of two types of epithelium, tall columnar mucinous cells and stratified eosinophilic cells. Electron microscopy revealed that they were endocervical glandlike mucinous cells and ciliated columnar epithelium reminiscent of the fallopian tube. As the mixture of EMBT and serous borderline tumor (seromucinous borderline tumor) occurs, these findings may show that the tumor shows MUllerian origin with two-way differentiation, or differentiation toward endocervical glands with metaplastic features as seen in reactive endocervical lesions.
宫颈内膜样黏液性交界性肿瘤（EMBT）是一种卵巢的独特病变，似乎未得到充分认识。它在日本女性中相对高发。与肠型黏液性交界性肿瘤（IMBT）相比，其特征包括双侧发病更为频繁、多房囊肿较少、与子宫内膜异位症相关、无假黏液瘤但可能伴有腹膜种植和淋巴结转移，以及死亡率较低。组织学上，它由两种上皮细胞混合组成，即高柱状黏液细胞和分层嗜酸性细胞。电子显微镜检查显示，它们是宫颈内膜腺样黏液细胞和类似于输卵管的纤毛柱状上皮。由于EMBT与浆液性交界性肿瘤（浆液黏液性交界性肿瘤）混合出现，这些发现可能表明该肿瘤起源于苗勒管，具有双向分化，或向具有化生特征的宫颈内膜腺体分化，如同反应性宫颈病变所见。
