Drozdz Maciej, Kowalczyk-Michałek Martyna, Kraśniak Andrzej, Sułowicz Władysław
Katedra i Klinika Nefrologii, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 2005;62(4):257-9.
Intradialytic anticoagulation is an essential element of the dialysis procedure. Patients with end stage renal failure, due to the repetitive nature of dialysis sessions are exposed in a chronic manner to side effects of drugs applied during the procedure. Popular administration of unfractionated heparin, concerning its unstable pharmacokinetic profile may cause thrombocytopenia, enhance hyperkalemia, osteoporosis, and lipid disturbances. In the past years, a clinical alternative to unfractionated heparin have become, as well as in dialysis therapy, low molecular weight heparins. Beside the beneficial pharmacokinetic aspect, these heparins are characterized by decreasing number and less intensified side effects associated with their administration.
透析期间的抗凝是透析过程中的一个重要环节。终末期肾衰竭患者由于透析疗程的重复性，会长期暴露于透析过程中所使用药物的副作用之下。普通肝素的广泛使用，鉴于其不稳定的药代动力学特征，可能会导致血小板减少、加重高钾血症、骨质疏松和脂质紊乱。在过去几年里，除了在透析治疗中，低分子量肝素已成为普通肝素的一种临床替代药物。除了有益的药代动力学方面，这些肝素的特点是与其使用相关的副作用数量减少且程度减轻。
