[Effects of cadmium on levels of insulin in rats].

OBJECTIVE

To explore the effect of cadmium on insulin in rats.

METHODS

96 of SD rats were administered with cadmium at different doses (0, 50, 100, 200 mg/L) by drinking water for 30 days, 60 days, and 90 days. The levels of insulin, the contents of cadmium in the blood, urine, and tissues (liver, kidney, and pancreas) were determined.

RESULTS

The level of insulin were decreased in the groups of 100 and 200 mg/L at the 30-day and in the group of 100 mg/L at the 60-day. Cadmium in blood and tissues (liver, kidney, and pancreas) were higher in exposed groups than those in control group. But the contents of cadmium in pancreas are lower than that in kidney and liver.

CONCLUSION

It is suggested that cadmium could be accumulated in pancreas. Then it maybe related to the change of the levels of insulin in serum.