Lei Li-jian, Jin Tai-yi, Zhou Yuan-fen
Department of Occupational Health School of Public Health, Fudan University, Shanghai 200032, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jan;24(1):3-6.
To investigate the effects of cadmium on the levels of insulin and blood glucose in exposed workers.
Ninety-eight cadmium-exposed workers in a smeltery in the mid-south district of our country were selected as the exposed subjects while the healthy doctors in the workers hospital who were not exposed to the cadmium were treated as the control. The subjects were grouped according to the exposure time, the blood cadmium and the urine cadmium. The variety of the level of serum insulin was investigated for the workers in different groups of the exposure time, the blood cadmium and the urine cadmium. The variety of the levels of the blood zinc and urine zinc were also determined. The relationships among the blood cadmium, the blood zinc and the serum insulin were analyzed.
The level of blood glucose in the group of the exposure time of more than 20 years [(4.9 +/- 0.6) mmol/L] was significantly higher than that in the control group [(4.6 +/- 0.60) mmol/L] with significantly statistical difference (P < 0.01). The level of serum insulin in the group of the exposure time of more than 10 years [(8.58 +/- 4.91) microIU/ml] was significantly lower than that in the control group [(11.57 +/- 5.42) microIU] with the significantly statistical difference (P < 0.05) and the level of serum insulin would be decreased significantly with the increase of the blood cadmium and urinary cadmium. The level of the urine zinc was increased significantly in the workers of the exposure time of more than 20 years. The correlation analysis indicated that the negative correlation was found between the level of serum insulin and the level of blood cadmium, as well as between the level of the serum insulin and the level of the urinary cadmium; the positive correlation was found between the level of blood glucose and the level of insulin, as well as between the level of blood glucose and the level of C peptide in serum.
The exposure to cadmium can cause the decrease of serum insulin and may affect the level of blood glucose.
探讨镉对接触镉作业工人胰岛素及血糖水平的影响。
选取我国中南地区某冶炼厂98名镉接触工人作为接触组，以该厂职工医院未接触镉的健康医生作为对照组。按接触时间、血镉、尿镉水平对研究对象进行分组，观察不同接触时间、血镉、尿镉水平组工人血清胰岛素水平的变化情况，同时测定血锌、尿锌水平，分析血镉、血锌与血清胰岛素之间的关系。
接触时间超过20年组的血糖水平[（4.9±0.6）mmol/L]明显高于对照组[（4.6±0.60）mmol/L]，差异有统计学意义（P<0.01）。接触时间超过10年组的血清胰岛素水平[（8.58±4.91）μIU/ml]明显低于对照组[（11.57±5.42）μIU]，差异有统计学意义（P<0.05），且血清胰岛素水平随血镉、尿镉水平升高而明显降低。接触时间超过20年的工人尿锌水平明显升高。相关性分析表明，血清胰岛素水平与血镉水平、尿镉水平均呈负相关；血糖水平与胰岛素水平、血清C肽水平均呈正相关。
镉接触可导致血清胰岛素水平降低，并可能影响血糖水平。
