Sjölund Maria, Tano Eva, Blaser Martin J, Andersson Dan I, Engstrand Lars
University Hospital, Uppsala, Sweden.
Emerg Infect Dis. 2005 Sep;11(9):1389-93. doi: 10.3201/eid1109.050124.
We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epidermidis strains were isolated and analyzed for clarithromycin susceptibility and presence of the erm(C) gene. We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment.
我们研究了一种包含克拉霉素的常见疗法如何影响正常定植的表皮葡萄球菌。收集了5名接受该疗法患者鼻孔的样本，分别在治疗前、治疗后即刻、治疗后1年和治疗后4年采集。从每位患者的每个样本中分离出表皮葡萄球菌菌株，并分析其对克拉霉素的敏感性以及erm(C)基因的存在情况。我们发现，治疗期间会选择出对大环内酯类耐药的表皮葡萄球菌菌株，并且在没有进一步抗菌治疗的情况下，同一耐药菌株可能会持续存在4年。
