Sponarova Jana, Mustard Kirsty J, Horakova Olga, Flachs Pavel, Rossmeisl Martin, Brauner Petr, Bardova Kristina, Thomason-Hughes Michaela, Braunerova Radka, Janovska Petra, Hardie D Grahame, Kopecky Jan
Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague, Czech Republic.
FEBS Lett. 2005 Nov 7;579(27):6105-10. doi: 10.1016/j.febslet.2005.09.078. Epub 2005 Oct 7.
The mechanisms controlling fat depot-specific metabolism are poorly understood. During starvation of mice, downregulation of lipogenic genes, suppression of fatty acid synthesis, and increases in lipid oxidation were all more pronounced in epididymal than in subcutaneous fat. In epididymal fat, relatively strong upregulation of uncoupling protein 2 and phosphoenolpyruvate carboxykinase genes was found. In mice maintained both at 20 and 30 degrees C, AMP-activated protein kinase was activated in epididymal but did not change in subcutaneous fat. Our results suggest that AMPK may have a role in the different response of various fat depots to starvation.
控制脂肪储存部位特异性代谢的机制目前还知之甚少。在小鼠饥饿期间，生脂基因的下调、脂肪酸合成的抑制以及脂质氧化的增加在附睾脂肪中比在皮下脂肪中更为明显。在附睾脂肪中，发现解偶联蛋白2和磷酸烯醇式丙酮酸羧激酶基因有相对较强的上调。在20摄氏度和30摄氏度环境下饲养的小鼠中，附睾脂肪中的AMP激活蛋白激酶被激活，而皮下脂肪中的该激酶则没有变化。我们的结果表明，AMPK可能在不同脂肪储存部位对饥饿的不同反应中发挥作用。
