Bari Ferenc, Tóth-Szuki Valéria, Domoki Ferenc, Kálmán János
Department of Physiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary.
Microvasc Res. 2005 Nov;70(3):121-8. doi: 10.1016/j.mvr.2005.09.001. Epub 2005 Oct 14.
Oscillations in laser Doppler signals derived from the forehead and forearm skin were analyzed in 77 healthy probands from 4 various age groups (ranging between 15 and 77 years) and 22 late-onset sporadic Alzheimer's disease (AD) patients. A characteristic pattern of oscillations in the microcirculatory blood flux ( approximately 8 cycles/min, 0.13 Hz) was observed in the forehead skin, the occurrence of which correlated inversely with age (r = 0.80). The occurrence of forehead vasomotion pattern was 100% in the teenagers, whereas it was significantly less in the elderly control subjects (32%) and in the AD patients (18%). Forearm reactive hyperemia was provoked by 1-min occlusion of the brachial artery, and the vascular reactivity was calculated. This phenomenon also proved to be age-dependent, but the process was not related to AD. Our results indicate that the lack of forehead vasomotion reflects aging better than does the forearm vasomotion. Both of these functions are preserved in AD.
对来自4个不同年龄组（年龄在15至77岁之间）的77名健康受试者以及22名晚发性散发性阿尔茨海默病（AD）患者的前额和前臂皮肤的激光多普勒信号振荡进行了分析。在前额皮肤中观察到微循环血流量振荡的特征模式（约8次/分钟，0.13赫兹），其出现与年龄呈负相关（r = 0.80）。青少年前额血管运动模式的出现率为100%，而在老年对照受试者（32%）和AD患者（18%）中显著降低。通过对肱动脉进行1分钟的阻断来诱发前臂反应性充血，并计算血管反应性。这一现象也被证明与年龄有关，但该过程与AD无关。我们的结果表明，前额血管运动的缺乏比前臂血管运动更能反映衰老。这两种功能在AD中均得以保留。
