Institute of Applied Radiation Chemistry, Lodz University of Technology, 90-924 Lodz, Poland.
Angionica Ltd., 90-924 Lodz, Poland.
Biosensors (Basel). 2024 Sep 25;14(10):459. doi: 10.3390/bios14100459.
This review summarizes studies dedicated to the assessment of microvascular function based on microcirculatory oscillations monitored by the Flow-Mediated Skin Fluorescence (FMSF) technique. Two approaches are presented. The first approach uses oscillatory parameters measured under normoxic conditions, expressed as flowmotion (FM), vasomotion (VM), and the normoxia oscillatory index (NOI). These parameters have been used for the identification of impaired microcirculatory oscillations associated with intense physical exercise, post-COVID syndrome, psychological stress, and erectile dysfunction. The second approach involves characterization of the microcirculatory response to hypoxia based on the measurement of hypoxia sensitivity (HS). The HS parameter is used to characterize microvascular complications in diabetes, such as diabetic kidney disease and diabetic foot ulcers. Based on research conducted by the authors of this review, the FMSF parameter ranges characterizing microvascular function are presented. The diagnostic approach to assessing microvascular function based on flowmotion monitored by the FMSF technique has a wide range of applications and the potential to be integrated into widespread medical practice.
这篇综述总结了基于血流介导皮肤荧光（Flow-Mediated Skin Fluorescence，FMSF）技术监测的微循环振荡来评估微血管功能的研究。介绍了两种方法。第一种方法使用在常氧条件下测量的振荡参数，以血流运动（Flowmotion，FM）、血管运动（Vasomotion，VM）和常氧振荡指数（Normoxia Oscillatory Index，NOI）表示。这些参数已用于识别与剧烈运动、新冠后综合征、心理压力和勃起功能障碍相关的受损的微循环振荡。第二种方法涉及基于缺氧敏感性（Hypoxia Sensitivity，HS）测量来描述缺氧对微循环的反应。HS 参数用于描述糖尿病微血管并发症，如糖尿病肾病和糖尿病足溃疡。根据本文作者的研究，提出了表征微血管功能的 FMSF 参数范围。基于 FMSF 技术监测血流运动的微血管功能评估的诊断方法具有广泛的应用，并且有可能整合到广泛的医疗实践中。
