Endo Daisuke, Ikeda Tetsuya, Ishida Yasushi, Yoshioka Daisuke, Nishimori Toshikazu
Division of Neurobiology, Miyazaki Medical College, University of Miyazaki, Kiyotake, Japan.
Neurosci Lett. 2006 Jan 9;392(1-2):114-7. doi: 10.1016/j.neulet.2005.09.005. Epub 2005 Oct 17.
Hemokinin-1 (HK-1) is a new peptide described as a member of the tachykinin family. HK-1 has biological effects similar to substance P (SP), a representative of the tachykinin family, following central administration. However, the biological function of HK-1 at the spinal level has not been well characterized. Thus, we investigated the effect of intrathecal administration of HK-1 by comparing it with that of SP. Intrathecal administration of HK-1 as well as SP at 10(-3) M caused pain-related behavior such as scratching. The scratching by HK-1 administration was inhibited by pretreatment with an antagonist of substance P receptor. In addition, SP (10(-8)-10(-6) M) decreased the latency of the withdrawal response of the hind paw to noxious thermal stimulation 20-30 min after intrathecal administration, whereas administration of HK-1 had little effect on this response. These results suggest that there may exist a proper receptor related to HK-1.
血激肽-1（HK-1）是一种新发现的肽，被归类为速激肽家族成员。中枢给药后，HK-1具有与速激肽家族代表物质P（SP）相似的生物学效应。然而，HK-1在脊髓水平的生物学功能尚未得到充分表征。因此，我们通过将鞘内注射HK-1与SP的效果进行比较，来研究其作用。鞘内注射10⁻³ M的HK-1和SP都会引发抓挠等与疼痛相关的行为。预先用P物质受体拮抗剂处理可抑制HK-1注射引起的抓挠行为。此外，鞘内注射后20 - 30分钟，SP（10⁻⁸ - 10⁻⁶ M）可缩短后爪对有害热刺激的撤腿反应潜伏期，而HK-1注射对此反应影响不大。这些结果表明，可能存在与HK-1相关的特定受体。
