Linhart Birgit, Valenta Rudolf
Division of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
Curr Opin Immunol. 2005 Dec;17(6):646-55. doi: 10.1016/j.coi.2005.09.010. Epub 2005 Oct 17.
Recombinant-allergen-based diagnostic tests enable the dissection and monitoring of the molecular reactivity profiles of allergic patients, resulting in more specific diagnosis, disease monitoring, prevention and therapy. In vitro experiments, animal studies and clinical trials in patients demonstrate that allergenic molecules can be engineered to induce different immune responses ranging from tolerance to vigorous immunity. The available data thus suggest that molecular engineering of the disease-related antigens is a technology that may be applicable not only for the design of allergy vaccines but also for the design of vaccines against infectious diseases, autoimmunity and cancer.
基于重组变应原的诊断测试能够剖析和监测过敏患者的分子反应性谱，从而实现更精准的诊断、疾病监测、预防和治疗。体外实验、动物研究以及患者临床试验表明，可以通过对变应原分子进行改造，使其引发从耐受性到强烈免疫反应等不同的免疫应答。现有数据因此表明，对疾病相关抗原进行分子工程改造是一项不仅可应用于过敏疫苗设计，还可应用于传染病、自身免疫性疾病和癌症疫苗设计的技术。
