Karoui O, Leimgruber A, Spertini F
Service d'immunologie et allergie, CHUV, 1011 Lausanne.
Rev Med Suisse. 2013 Jan 9;9(368):22-7.
Compared to total allergenic extracts, recombinant allergens available for specific IgE measurement represent an important advance in the diagnosis and treatment of IgE-mediated allergies. Recombinant allergens lead to define the sensitization profile of allergic patients, to identify markers of sensitization and to understand better polysensitivities related to cross-reactions and markers of severity of allergic reactions. They also contribute to the decision to establish tolerance induction (allergen specific immunotherapy) and the optimal selection of the allergenic composition of the vaccine.
与总变应原提取物相比，可用于特异性IgE检测的重组变应原代表了IgE介导的过敏症诊断和治疗方面的一项重要进展。重组变应原有助于明确过敏患者的致敏谱，识别致敏标志物，并更好地理解与交叉反应和过敏反应严重程度标志物相关的多重致敏情况。它们还有助于决定是否开展耐受性诱导（变应原特异性免疫疗法）以及疫苗变应原成分的最佳选择。
