Ying Lei, Marino Jillian, Hussain S Perwez, Khan Mohammed A, You Shaojin, Hofseth Anne B, Trivers Glennwood E, Dixon Dan A, Harris Curtis C, Hofseth Lorne J
Laboratory of Inflammatory-Driven Carcinogenesis, Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy.
Cancer Res. 2005 Oct 15;65(20):9132-6. doi: 10.1158/0008-5472.CAN-05-1358.
Chronic inflammation contributes to tumorigenesis. The retinoblastoma protein (pRb), in its hyperphosphorylated form, releases E2 promoter binding factor-1 (E2F1), which drives cell proliferation. Here, we show that pRb is hyperphosphorylated in both mouse and human colitis. In turn, pRb hyperphosphorylation is associated with release of E2F1 from pRb, resulting in the activation of E2F1 target molecules involved in proliferation and apoptosis. These observations provide insight into the in vivo mechanisms associated with chronic colon inflammation and increased colon cancer risk.
慢性炎症促进肿瘤发生。视网膜母细胞瘤蛋白（pRb）以其过度磷酸化形式释放E2启动子结合因子-1（E2F1），后者驱动细胞增殖。在此，我们表明pRb在小鼠和人类结肠炎中均发生过度磷酸化。反过来，pRb过度磷酸化与E2F1从pRb释放相关，导致参与增殖和凋亡的E2F1靶分子激活。这些观察结果为与慢性结肠炎症和结肠癌风险增加相关的体内机制提供了见解。
