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A comprehensive review of the roles of E2F1 in colon cancer.E2F1在结肠癌中作用的全面综述。
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2
Roles of E2F1 in mesangial cell proliferation in vitro.E2F1在体外系膜细胞增殖中的作用。
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Regulation of the G1/S transition phase in mesangial cells by E2F1.E2F1对系膜细胞中G1/S转换期的调控。
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Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.小鼠E2F1启动子的生长调节需要多种DNA元件。
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[Interaction of E2F/Rb family members with factor binding to co-repressor element on B-myb and E2F1 promoters].[E2F/Rb家族成员与结合于B-myb和E2F1启动子上共抑制元件的因子之间的相互作用]
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本文引用的文献

1
YY1 promotes colorectal cancer proliferation through the /E2F1 axis.YY1通过/E2F1轴促进结直肠癌增殖。
Am J Cancer Res. 2019 Dec 1;9(12):2679-2692. eCollection 2019.
2
E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors.E2F1通过定位于断裂位点并增强同源重组因子的表达来促进DNA断裂修复。
Exp Mol Med. 2019 Sep 18;51(9):1-12. doi: 10.1038/s12276-019-0307-2.
3
Colorectal Cancer and Metabolism.结直肠癌与代谢
Curr Colorectal Cancer Rep. 2018 Dec;14(6):226-241. doi: 10.1007/s11888-018-0420-y. Epub 2018 Nov 16.
4
FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression.FOXM1 通过调节 TYMS 表达来调节结直肠癌细胞对 5-FU 的耐药性。
Sci Rep. 2019 Feb 6;9(1):1505. doi: 10.1038/s41598-018-38017-0.
5
FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1-TYMS axis uncoupling in 5-FU resistance.FOXM1 通过胸苷酸合成酶（TYMS）调节胆管癌对 5-氟尿嘧啶的敏感性：FOXM1-TYMS 轴解耦在 5-FU 耐药中的意义。
Cell Death Dis. 2018 Dec 11;9(12):1185. doi: 10.1038/s41419-018-1235-0.
6
E2F1-mediated MNX1-AS1-miR-218-5p-SEC61A1 feedback loop contributes to the progression of colon adenocarcinoma.E2F1 介导的 MNX1-AS1-miR-218-5p-SEC61A1 反馈环促进结肠腺癌的进展。
J Cell Biochem. 2019 Apr;120(4):6145-6153. doi: 10.1002/jcb.27902. Epub 2018 Oct 25.
7
Expressions and prognostic values of the transcription factors in human breast carcinoma.转录因子在人乳腺癌中的表达及其预后价值
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8
siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease.用于控制克罗恩病中细胞周期蛋白D1和E2F1表达的小干扰RNA传递
Transl Med UniSa. 2018 Mar 31;17:25-33. eCollection 2017 Jul.
9
Tristetraprolin activation by resveratrol inhibits the proliferation and metastasis of colorectal cancer cells.白藜芦醇激活三肽基脯氨酰顺反异构酶抑制结直肠癌细胞的增殖和转移。
Int J Oncol. 2018 Sep;53(3):1269-1278. doi: 10.3892/ijo.2018.4453. Epub 2018 Jun 25.
10
E2F1/SP3/STAT6 axis is required for IL-4-induced epithelial-mesenchymal transition of colorectal cancer cells.E2F1/SP3/STAT6 轴是 IL-4 诱导结直肠癌细胞上皮-间充质转化所必需的。
Int J Oncol. 2018 Aug;53(2):567-578. doi: 10.3892/ijo.2018.4429. Epub 2018 Jun 5.

E2F1在结肠癌中作用的全面综述。

A comprehensive review of the roles of E2F1 in colon cancer.

作者信息

Fang Zejun, Lin Min, Li Chunxiao, Liu Hong, Gong Chaoju

机构信息

Central Laboratory, Sanmen People's Hospital of Zhejiang, Sanmenwan Branch of The First Affiliated Hospital, College of Medicine, Zhejiang University Sanmen 317100, China.

Department of Gastroenterology, Sanmen People's Hospital of Zhejiang, Sanmenwan Branch of The First Affiliated Hospital, College of Medicine, Zhejiang University Sanmen 317100, China.

出版信息

Am J Cancer Res. 2020 Mar 1;10(3):757-768. eCollection 2020.

PMID:32266089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7136928/
Abstract

E2F transcription factor 1 (E2F1) is a member of the E2F family of transcription factors. E2F1 binds to DNA with dimerization partner (DP) proteins through an E2 recognition site. The dissociation of E2F1 from retinoblastoma (Rb) protein recovers its transcriptional activity, which drives the cell cycle from the G1 to S phase. E2F1 has been shown to be involved in cellular proliferation, differentiation, and apoptosis in colon cancer. It was recently found that E2F1 also participates in the metastasis and chemoresistance of colon cancer. There are abundant experimental data regarding the actions of E2F1, which can be grouped as either pro-tumorigenic or pro-apoptotic. Despite a growing interest and plentiful data, there is currently no review that focuses on the role of E2F1 in colon cancer. Research on E2F1 and colon cancer has been scattered over various genes and microRNAs (miRNAs) that affect E2F1 expression. Here, we provide the first review that aims to consider and dissect all of the elucidated complex behaviors of E2F1 in colon cancer. This review also provides an analysis and conclusion regarding the current understanding of E2F1 in colon cancer in order to facilitate the direction of future research.

摘要

E2F转录因子1（E2F1）是E2F转录因子家族的成员之一。E2F1通过E2识别位点与二聚化伴侣（DP）蛋白结合于DNA。E2F1与视网膜母细胞瘤（Rb）蛋白解离后恢复其转录活性，从而驱动细胞周期从G1期进入S期。已有研究表明E2F1参与结肠癌的细胞增殖、分化和凋亡过程。最近发现E2F1还参与结肠癌的转移和化疗耐药。关于E2F1作用的实验数据丰富，可分为促肿瘤发生或促凋亡两类。尽管人们对其兴趣日增且数据丰富，但目前尚无专注于E2F1在结肠癌中作用的综述。关于E2F1与结肠癌的研究分散于影响E2F1表达的各种基因和微小RNA（miRNA）。在此，我们提供首篇综述，旨在考量和剖析E2F1在结肠癌中已阐明的所有复杂行为。本综述还对目前对E2F1在结肠癌中的理解进行分析并得出结论，以推动未来研究方向。