E2F1在结肠癌中作用的全面综述。
A comprehensive review of the roles of E2F1 in colon cancer.
作者信息
Fang Zejun, Lin Min, Li Chunxiao, Liu Hong, Gong Chaoju
机构信息
Central Laboratory, Sanmen People's Hospital of Zhejiang, Sanmenwan Branch of The First Affiliated Hospital, College of Medicine, Zhejiang University Sanmen 317100, China.
Department of Gastroenterology, Sanmen People's Hospital of Zhejiang, Sanmenwan Branch of The First Affiliated Hospital, College of Medicine, Zhejiang University Sanmen 317100, China.
出版信息
Am J Cancer Res. 2020 Mar 1;10(3):757-768. eCollection 2020.
E2F transcription factor 1 (E2F1) is a member of the E2F family of transcription factors. E2F1 binds to DNA with dimerization partner (DP) proteins through an E2 recognition site. The dissociation of E2F1 from retinoblastoma (Rb) protein recovers its transcriptional activity, which drives the cell cycle from the G1 to S phase. E2F1 has been shown to be involved in cellular proliferation, differentiation, and apoptosis in colon cancer. It was recently found that E2F1 also participates in the metastasis and chemoresistance of colon cancer. There are abundant experimental data regarding the actions of E2F1, which can be grouped as either pro-tumorigenic or pro-apoptotic. Despite a growing interest and plentiful data, there is currently no review that focuses on the role of E2F1 in colon cancer. Research on E2F1 and colon cancer has been scattered over various genes and microRNAs (miRNAs) that affect E2F1 expression. Here, we provide the first review that aims to consider and dissect all of the elucidated complex behaviors of E2F1 in colon cancer. This review also provides an analysis and conclusion regarding the current understanding of E2F1 in colon cancer in order to facilitate the direction of future research.
E2F转录因子1（E2F1）是E2F转录因子家族的成员之一。E2F1通过E2识别位点与二聚化伴侣（DP）蛋白结合于DNA。E2F1与视网膜母细胞瘤（Rb）蛋白解离后恢复其转录活性，从而驱动细胞周期从G1期进入S期。已有研究表明E2F1参与结肠癌的细胞增殖、分化和凋亡过程。最近发现E2F1还参与结肠癌的转移和化疗耐药。关于E2F1作用的实验数据丰富，可分为促肿瘤发生或促凋亡两类。尽管人们对其兴趣日增且数据丰富，但目前尚无专注于E2F1在结肠癌中作用的综述。关于E2F1与结肠癌的研究分散于影响E2F1表达的各种基因和微小RNA（miRNA）。在此，我们提供首篇综述，旨在考量和剖析E2F1在结肠癌中已阐明的所有复杂行为。本综述还对目前对E2F1在结肠癌中的理解进行分析并得出结论，以推动未来研究方向。
Zotero 插件