芬兰唐氏综合征患者的癌症发病率：一项基于人群的研究。

Cancer incidence of persons with Down syndrome in Finland: a population-based study.

作者信息

Patja Kristiina, Pukkala Eero, Sund Reijo, Iivanainen Matti, Kaski Markus

机构信息

National Public Health Institute, Helsinki, Finland.

出版信息

Int J Cancer. 2006 Apr 1;118(7):1769-72. doi: 10.1002/ijc.21518.

DOI:10.1002/ijc.21518

PMID:16231334

Abstract

Individuals with Down syndrome (DS) have a predisposition to leukaemia and testicular cancer, but data on the incidence of cancers are yet sparse. A cohort of 3,581 persons with DS was identified from a National Registry of Finnish persons with intellectual disability collected between 1978 and 1986 and followed-up for cancer incidence until 2002. Standardised incidence ratios (SIRs) were defined as ratios of observed number of cancer cases to those expected from the national cancer incidence rates, by age and sex. The overall cancer risk was equal to that of the general population, but a significantly high risk of leukaemia (SIR 10.5, CI 95% 6.6-15.8) and testicular cancer (SIR4.8, CI 95% 1.8-10.4) was found.

摘要

唐氏综合征（DS）患者易患白血病和睾丸癌，但癌症发病率的数据仍然稀少。从1978年至1986年收集的芬兰智障人士国家登记册中确定了一组3581名DS患者，并对其癌症发病率进行随访，直至2002年。标准化发病率（SIR）定义为按年龄和性别观察到的癌症病例数与根据国家癌症发病率预期的病例数之比。总体癌症风险与普通人群相同，但发现白血病（SIR 10.5，95%CI 6.6 - 15.8）和睾丸癌（SIR 4.8，95%CI 1.8 - 10.4）的风险显著较高。