Ruzsás C, Biró-Gosztonyi M, Wöller L, Mess B
Acta Biol Acad Sci Hung. 1979;30(4):335-45.
The fertility-inhibiting effects of long-term (8 weeks) consumption of maize infected with a fungus producing F2 toxin (zearalenone) was studied in adult male and female albino rats. The fertility rate was further decreased by 25-30% if the animals were kept on contaminated diet up to 14 weeks. The gonadal weight was decreased, follicular maturation and spermatogenesis were disturbed. The toxic diet consumed by mothers during pregnancy and lactation induced permanent changes in reproductive organs, disorders in vaginal cyclicity and disturbed fertility in the offspring. Neonatal administration of purified F2 toxin provoked similar changes. It is suggested that this fungal toxin may cause sterility syndrome in the offspring, similar to that produced by androgen or estrogen administration.
研究了成年雄性和雌性白化大鼠长期（8周）食用感染产生F2毒素（玉米赤霉烯酮）的真菌的玉米后的生育抑制作用。如果动物持续食用受污染的饲料长达14周，生育率会进一步降低25%-30%。性腺重量减轻，卵泡成熟和精子发生受到干扰。母亲在怀孕和哺乳期间食用有毒饲料会导致生殖器官发生永久性变化、阴道周期紊乱以及后代生育能力受损。对新生儿施用纯化的F2毒素也会引发类似变化。有人认为，这种真菌毒素可能会导致后代出现不育综合征，类似于施用雄激素或雌激素所产生的不育综合征。
