Sivaprasad S, Bunce C, Wormald R
Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, UK.
Br J Ophthalmol. 2005 Nov;89(11):1420-2. doi: 10.1136/bjo.2005.073817.
To examine the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of cystoid macular oedema (CMO) following cataract surgery.
Systematic literature review of randomised controlled trials (RCTs) that evaluated the effects of NSAIDs in the treatment of CMO following cataract surgery was done according to the Cochrane Collaboration methodology.
Seven trials involving a total of 266 participants were included. Four trials studied the effects of NSAIDs in chronic CMO while the other three trials examined the effect of NSAIDs in acute CMO. Little evidence of effectiveness was found for oral indomethacin and topical fenoprofen for chronic CMO in two small trials. Treatment with topical 0.5% ketorolac for chronic CMO was found to be effective in two trials. Three trials examined the effect of topical NSAIDs on acute CMO. The comparisons among these studies were of a NSAID to placebo, prednisolone or another NSAID. Because of considerable heterogeneity between these study designs, their results were not combined in a meta-analysis.
A positive effect of topical NSAID (0.5% ketorolac tromethamine ophthalmic solution) on chronic CMO was noted. However, there is not enough evidence to show the effectiveness of NSAIDs in acute CMO following cataract surgery.
探讨非甾体类抗炎药（NSAIDs）治疗白内障术后黄斑囊样水肿（CMO）的有效性。
按照Cochrane协作网方法，对评估NSAIDs治疗白内障术后CMO效果的随机对照试验（RCTs）进行系统文献综述。
纳入7项试验，共266名参与者。4项试验研究NSAIDs对慢性CMO的影响，另外3项试验研究NSAIDs对急性CMO的影响。两项小型试验中，口服吲哚美辛和局部用非诺洛芬治疗慢性CMO几乎未发现有效证据。两项试验发现，局部用0.5%酮咯酸治疗慢性CMO有效。3项试验研究了局部用NSAIDs对急性CMO的影响。这些研究的比较是在NSAIDs与安慰剂、泼尼松龙或另一种NSAIDs之间进行。由于这些研究设计之间存在相当大的异质性，其结果未合并进行荟萃分析。
注意到局部用NSAID（0.5%酮咯酸氨丁三醇滴眼液）对慢性CMO有积极作用。然而，没有足够证据表明NSAIDs对白内障术后急性CMO有效。
