Levy S L, Burnham W M, Bishai A, Hwang P A
Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada.
Can J Neurol Sci. 1992 May;19(2):201-3.
Vitamin E (d-alpha-tocopherol) has proven to be a useful adjunct to anticonvulsant drugs in clinical studies. Improvement has occurred even in patients with complex partial seizures, which are often resistant to drug therapy. In animals, vitamin E is effective against ferrous chloride seizures, hyperbaric oxygen seizures and penicillin-induced seizures. It has failed, however, to show anticonvulsant effects in the standard animal models used for drug screening--the maximal electroshock and threshold pentylenetetrazol tests. The present experiments were designed to further explore the anti-epileptic actions of vitamin E in animals. Three models related to complex partial epilepsy were used: 1) the development of amygdala-kindled seizures; 2) the development of electrically-induced status in kindled animals; and 3) the development of kainic-acid seizures. Vitamin E failed to produce significant effects in any of the models.
在临床研究中，维生素E（d-α-生育酚）已被证明是抗惊厥药物的有用辅助剂。即使是患有复杂部分性癫痫发作（通常对药物治疗有抗性）的患者也有病情改善。在动物中，维生素E对氯化亚铁诱发的癫痫发作、高压氧诱发的癫痫发作和青霉素诱发的癫痫发作有效。然而，在用于药物筛选的标准动物模型——最大电休克和阈下戊四氮试验中，它未能显示出抗惊厥作用。本实验旨在进一步探索维生素E在动物中的抗癫痫作用。使用了三种与复杂部分性癫痫相关的模型：1）杏仁核点燃癫痫发作的发展；2）点燃动物中电诱发癫痫持续状态的发展；3）红藻氨酸诱发癫痫发作的发展。维生素E在任何一个模型中均未产生显著效果。
