Eggebrecht Holger, Lönn Lars, Herold Ulf, Breuckmann Frank, Leyh Rainer, Jakob Heinz G, Erbel Raimund
Department of Cardiology, West-German Heart Center Essen, University of Duisburg-Essen, Essen, Germany.
Curr Opin Cardiol. 2005 Nov;20(6):477-83. doi: 10.1097/01.hco.0000181481.86025.a6.
To review the concepts and current clinical results of endovascular stent-graft placement for acute complicated type B aortic dissection.
The optimal treatment for patients with dissections confined to the descending aorta (Stanford type B-AD) remains a matter of debate. Usually, antihypertensive medical therapy with strict blood pressure lowering below 135/80 mm Hg represents the first choice for patients with uncomplicated type B-AD. Patients with acute complicated type B-AD remain a major therapeutic challenge because surgery of the descending aorta is still associated with high morbidity and mortality. In 1999, endovascular stent-graft placement was introduced as a novel, less invasive treatment option for patients with type B aortic dissection. Current indications include acute (contained) aortic rupture, symptomatic ischemic branch vessel involvement, early aortic expansion, or unrelenting pain. So far, few studies on stent-graft placement in patients with acute complicated aortic dissection have been published reporting an early mortality between 0 and approximately 20%.
To date, there is limited experience with endovascular stent-graft placement for acute complicated type B aortic dissection demonstrating its feasibility and life-saving potential. The endovascular approach can avoid the major trauma of open surgery and should help to get patients out of the acute life-threatening phase of the disease; however, long-term results are needed to assess the durability of this treatment.
回顾急性复杂性B型主动脉夹层腔内支架移植物置入的概念及当前临床结果。
对于局限于降主动脉的夹层患者(斯坦福B型主动脉夹层),最佳治疗方法仍存在争议。通常,将血压严格控制在135/80 mmHg以下的降压药物治疗是单纯性B型主动脉夹层患者的首选。急性复杂性B型主动脉夹层患者仍然是一个重大的治疗挑战,因为降主动脉手术仍与高发病率和死亡率相关。1999年,腔内支架移植物置入作为一种新型、侵入性较小的治疗方法被引入用于B型主动脉夹层患者。目前的适应症包括急性(局限性)主动脉破裂、有症状的缺血性分支血管受累、早期主动脉扩张或持续性疼痛。到目前为止,关于急性复杂性主动脉夹层患者支架移植物置入的研究很少发表,报道的早期死亡率在0%至约20%之间。
迄今为止,急性复杂性B型主动脉夹层腔内支架移植物置入的经验有限,证明了其可行性和挽救生命的潜力。腔内治疗方法可以避免开放手术的重大创伤,并应有助于患者摆脱疾病的急性危及生命阶段;然而,需要长期结果来评估这种治疗的持久性。