生殖道巨细胞病毒感染与细菌性阴道病之间的关联。

Association between genital tract cytomegalovirus infection and bacterial vaginosis.

作者信息

Ross Shannon A, Novak Zdenek, Ashrith Guha, Rivera Lisa B, Britt William J, Hedges Spencer, Schwebke Jane R, Boppana And Suresh

机构信息

Department of Pediatrics, University of Alabama at Birmingham, 35233, USA.

出版信息

J Infect Dis. 2005 Nov 15;192(10):1727-30. doi: 10.1086/497150. Epub 2005 Oct 7.

DOI:10.1086/497150

PMID:16235170

Abstract

Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.

摘要

患有性传播疾病（STD）和细菌性阴道病（BV）的女性巨细胞病毒（CMV）血清阳性率和CMV血清转化发生率更高。为了明确生殖道CMV感染与BV之间的关联，对一家STD诊所的52名女性的阴道冲洗样本进行了分析。患有BV的女性在下生殖道排出CMV的人数显著多于未患BV的女性。此外，大多数排出CMV的女性感染了不止一种病毒株。这些结果表明，BV的存在促进了局部CMV复制以及多种CMV毒株的感染。