Yavari P, Mosavizadeh M, Sadrol-Hefazi B, Mehrabi Y
Department of Health and Community Medicine, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, P.O. Box 19395-4719, Iran.
Asian Pac J Cancer Prev. 2005 Jul-Sep;6(3):370-5.
Breast cancer is a common malignancy for women in most parts of the world and the incidence in Iranian women is growing. The patients are relatively younger than their western counterparts. The present hospital based case-control study was designed to determine roles of reproductive factors for breast cancer among women in Iran. Conducted at a teaching hospital in Tehran, Iran, in 2004, the study covered a total of 303 cases of breast cancer and 303 healthy controls. Cases were identified through the Oncology Department of a university hospital and controls were collected from other wards or out-patient clinics at the same hospital. Control subjects were matched to patients for age. Informed consent was obtained from all cases and controls then demographic and reproductive factors were ascertained by in-person interview using a constructed questionnaire. Odds ratios and their 95% confidence intervals for breast cancer were derived using logistic regression analysis. The mean +/-SD ages of cases and controls were 48.8 +/- 9.8 and 50.2 +/- 11.1 years, respectively, (range 24-84). The final model for multiple analysis indicated that never married, post menopause, age at first live birth, number of live births, use of oral contraceptive pills, and history of chest X-rays between adolescence and 30 yrs of age, were significantly associated with breast cancer. Variables such as higher education, early age at menarche, abortion, breast feeding and its duration were not significant risk factors.
乳腺癌是世界上大多数地区女性常见的恶性肿瘤，伊朗女性的发病率正在上升。这些患者相对比西方的患者年轻。目前这项基于医院的病例对照研究旨在确定伊朗女性中生殖因素在乳腺癌发病中的作用。该研究于2004年在伊朗德黑兰的一家教学医院进行，共纳入303例乳腺癌患者和303名健康对照者。病例通过大学医院的肿瘤科确定，对照者从同一家医院的其他病房或门诊收集。对照者与患者按年龄匹配。所有病例和对照者均获得知情同意，然后通过使用编制好的问卷进行面对面访谈来确定人口统计学和生殖因素。使用逻辑回归分析得出乳腺癌的比值比及其95%置信区间。病例组和对照组的平均年龄±标准差分别为48.8±9.8岁和50.2±11.1岁（范围24 - 84岁）。多因素分析的最终模型表明，从未结婚、绝经后、首次生育年龄、生育次数、口服避孕药的使用以及青春期至30岁之间的胸部X光检查史与乳腺癌显著相关。诸如高等教育、初潮年龄早、流产、母乳喂养及其持续时间等变量不是显著的危险因素。
