实验性诱导糖尿病大鼠中类花生酸对心血管敏感性的影响。

Cardiovascular sensitivity changes to eicosanoids in rats with experimentally induced diabetes mellitus.

作者信息

Hodgson W C, Sikorski B W, King R G

机构信息

Department of Pharmacology, Monash University, Clayton, Victoria, Australia.

出版信息

Clin Exp Pharmacol Physiol. 1992 Jan;19(1):9-15. doi: 10.1111/j.1440-1681.1992.tb00391.x.

DOI:10.1111/j.1440-1681.1992.tb00391.x

PMID:1623640

Abstract

This paper attempts to provide a short review of the evidence for: 1. Increased platelet production of thromboxane A2 and reduced vascular production of prostacyclin in the human and also animal models of diabetes. 2. Reduced depressor responsiveness to arachidonic acid of anaesthetized alloxan- and streptozotocin-induced diabetic rats. 3. Enhanced constrictor responsiveness to arachidonic acid in blood-perfused hindquarters of alloxan-induced diabetic rats. 4. Potentiation by the thromboxane A2-mimetic, U46619, of constrictor responses to 5-hydroxytryptamine in Krebs'-perfused hindquarters and kidneys of both control and alloxan-induced diabetic rats. 5. Alterations during diabetes in production of, and responsiveness to, eicosanoids may contribute to the cardiovascular changes which occur in this disease.

摘要

本文试图简要综述以下几方面的证据

在人类及糖尿病动物模型中，血小板生成血栓素A2增加，血管生成前列环素减少。2. 麻醉状态下，用四氧嘧啶和链脲佐菌素诱导的糖尿病大鼠对花生四烯酸的降压反应性降低。3. 四氧嘧啶诱导的糖尿病大鼠血液灌注后肢对花生四烯酸的收缩反应性增强。4. 血栓素A2模拟物U46619可增强对照大鼠和四氧嘧啶诱导的糖尿病大鼠经克雷布斯液灌注的后肢及肾脏对5-羟色胺的收缩反应。5. 糖尿病期间类二十烷酸生成及反应性的改变可能促成了该疾病中发生的心血管变化。