Roth D M, Reibel D K, Lefer A M
Diabetologia. 1983 May;24(5):372-6. doi: 10.1007/BF00251827.
Vascular responsiveness to vasoactive eicosanoids as well as vascular prostacyclin and thromboxane production was investigated in 7-10 weeks alloxan-diabetic rats. Aortic rings from diabetic rats exhibited increased responsiveness to carbocyclic thromboxane A2, a thromboxane analogue, when compared to control rat aortae. Isolated perfused hearts of diabetic rats showed increased vascular responsiveness to 9,11-methanoepoxy PGH2 (U-46619), an endoperoxide analogue. Diabetes resulted in a reduction in prostacyclin generation by isolated incubated aortae which was overcome by the addition of arachidonic acid but not by homogenization of incubated aortic tissue. In contrast, prostacyclin, but not thromboxane, generation was elevated in isolated perfused hearts of diabetic animals in response to moderate doses of arachidonic acid, but at high doses of arachidonate, more thromboxane was formed by perfused hearts of diabetic rats. These results suggest that different vessels can either increase or decrease their prostaglandin production in response to diabetes. The alterations in prostanoid production may be due to differential changes in prostacyclin and thromboxane synthesis in vessels which, in turn, may be related to the changes in vascular responsiveness.
在7 - 10周龄的四氧嘧啶糖尿病大鼠中，研究了血管对血管活性类二十烷酸的反应性以及血管前列环素和血栓素的生成。与对照大鼠主动脉相比，糖尿病大鼠的主动脉环对血栓素类似物碳环血栓素A2表现出更高的反应性。糖尿病大鼠的离体灌注心脏对内过氧化物类似物9,11 - 甲撑环氧PGH2（U - 46619）表现出更高的血管反应性。糖尿病导致离体孵育的主动脉生成前列环素减少，添加花生四烯酸可克服这一现象，但孵育的主动脉组织匀浆则不能克服。相反，在离体灌注的糖尿病动物心脏中，中等剂量的花生四烯酸可使前列环素生成增加，但血栓素生成无变化；而在高剂量花生四烯酸作用下，糖尿病大鼠灌注心脏形成的血栓素更多。这些结果表明，不同血管对糖尿病的反应可能表现为前列腺素生成增加或减少。类前列腺素生成的改变可能是由于血管中前列环素和血栓素合成的差异性变化，进而可能与血管反应性的改变有关。
