Banwell Martin G, Bezos Anna, Burns Christopher, Kruszelnicki Irma, Parish Christopher R, Su Stephen, Sydnes Magne O
Research School of Chemistry, The Australian National University, Canberra ACT 0200, Australia.
Bioorg Med Chem Lett. 2006 Jan 1;16(1):181-5. doi: 10.1016/j.bmcl.2005.09.032. Epub 2005 Oct 19.
Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents.
