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Expedient syntheses of antofine and cryptopleurine via intramolecular 1,3-dipolar cycloaddition.
J Org Chem. 2007 Jun 22;72(13):4886-91. doi: 10.1021/jo070668x. Epub 2007 May 25.
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Synthesis of phenanthroindolizidine alkaloids and evaluation of their antitumor activities and toxicities.
Bioorg Med Chem Lett. 2011 Oct 1;21(19):5978-81. doi: 10.1016/j.bmcl.2011.07.120. Epub 2011 Aug 6.

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Potential applications of antofine and its synthetic derivatives in cancer therapy: structural and molecular insights.
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Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents.
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Use of chiral-pool approach into -thieno analogues of the scarce bioactive phenanthroquinolizidine alkaloids.
Tetrahedron. 2016 Jun 9;72(23):3221-3231. doi: 10.1016/j.tet.2016.04.047. Epub 2016 Apr 21.
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Total synthesis of (+)-antofine and (-)-cryptopleurine.
European J Org Chem. 2013 May 1;2013(15). doi: 10.1002/ejoc.201300200.
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Cryptopleurine analogs with modification of e ring exhibit different mechanism to rac-cryptopleurine and tylophorine.
PLoS One. 2012;7(12):e51138. doi: 10.1371/journal.pone.0051138. Epub 2012 Dec 10.
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Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine.
J Org Chem. 2010 Sep 3;75(17):6019-22. doi: 10.1021/jo101051w.

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Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy.
Curr Bioact Compd. 2009 Mar 1;5(1):2-19. doi: 10.2174/157340709787580928.
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Total synthesis of (S)-(+)-tylophorine via enantioselective intramolecular alkene carboamination.
J Org Chem. 2008 Aug 1;73(15):6045-7. doi: 10.1021/jo801024h. Epub 2008 Jun 28.
4
Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.
Bioorg Med Chem Lett. 2007 Aug 1;17(15):4338-42. doi: 10.1016/j.bmcl.2007.05.021. Epub 2007 May 16.
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Novel mode of action of tylophorine analogs as antitumor compounds.
Cancer Res. 2004 Jan 15;64(2):678-88. doi: 10.1158/0008-5472.can-03-1904.

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