作为磷酸酶抑制剂的3-取代中氮茚-1-甲腈衍生物
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.
作者信息
Weide Timo, Arve Lars, Prinz Heino, Waldmann Herbert, Kessler Horst
机构信息
Department Chemie, Lehrstuhl II für Organische Chemie, Technische Universität München, Lichtenbergstr. 4, D-85747 Garching, Germany.
出版信息
Bioorg Med Chem Lett. 2006 Jan 1;16(1):59-63. doi: 10.1016/j.bmcl.2005.09.051. Epub 2005 Oct 19.
In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.
在旨在发现用于医学应用的新型支架的研究过程中，我们合成了一系列3-取代中氮茚-1-腈衍生物。其中一些对参与传染病的MPtpA/MPtpB磷酸酶具有活性。我们在此报告一系列中氮茚的固相合成及抗磷酸酶活性。
Zotero 插件