通过氧化C-H官能化和环化反应实现银介导的中氮茚合成
Silver-Mediated Synthesis of Indolizines via Oxidative C-H functionalization and cyclization.
作者信息
Pandya Amit N, Fletcher James T, Villa Eric M, Agrawal Devendra K
机构信息
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.
Department of Chemistry, Creighton University, Omaha, NE 68178, USA Tel: (402) 280 2938;
出版信息
Tetrahedron Lett. 2014 Dec 10;55(50):6922-6924. doi: 10.1016/j.tetlet.2014.10.112.
Abstract
An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance and selectivity. The structure of the product was confirmed by the X-ray crystallographic studies. The AgCO required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.
摘要
已经证明了一种通过氧化C-H官能化和环化一步从容易获得的起始原料合成中氮茚的有效策略。该方案具有广泛的底物范围、高官能团耐受性和选择性。产物的结构通过X射线晶体学研究得到证实。该串联反应所需的AgCO在经过氧化反应后可以回收再利用。
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