Li Jane, Crasto Curtis F, Weinberg James S, Amiji Mansoor, Shenoy Dinesh, Sridhar Srinivas, Bubley Glenn J, Jones Graham B
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Bioorg Med Chem Lett. 2005 Dec 15;15(24):5558-61. doi: 10.1016/j.bmcl.2005.08.108. Epub 2005 Oct 19.
A family of differentially substituted poly(ethyleneglycol) building blocks has been assembled from commercially available material. Their utility is demonstrated by formation of amino acid conjugates, image contrast agents, gold nanoparticles, and functional antibody conjugates. Application in the cellular trafficking of antitumoral agent conjugates is expected.
一系列不同取代的聚乙二醇结构单元已由市售材料组装而成。通过形成氨基酸缀合物、影像造影剂、金纳米颗粒和功能性抗体缀合物，证明了它们的实用性。预计它们可应用于抗肿瘤药物缀合物的细胞运输。
