Baton Luke A, Ranford-Cartwright Lisa C
Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, UK, G12 8QQ.
Trends Parasitol. 2005 Dec;21(12):573-80. doi: 10.1016/j.pt.2005.09.012. Epub 2005 Oct 19.
Plasmodium spp. undergo a complex obligate developmental cycle within their invertebrate vectors that enables transmission between vertebrate hosts. This developmental cycle involves sexual reproduction and then asexual multiplication, separated by phases of invasion and colonization of distinct vector tissues. As with other stages in the Plasmodium life cycle, there is exquisite adaptation of the malaria parasite to its changing environment as it transforms within the blood of its vertebrate host, through the different tissues of its mosquito vector and onwards to infect a new vertebrate host. Despite the intricacies inherent in these successive transformations, malaria parasites remain staggeringly successful at disseminating through their vertebrate host populations.
疟原虫在其无脊椎动物媒介体内经历复杂的专性发育循环，从而实现脊椎动物宿主之间的传播。这个发育循环包括有性生殖，然后是无性繁殖，中间穿插着对不同媒介组织的侵入和定殖阶段。与疟原虫生命周期中的其他阶段一样，疟原虫在脊椎动物宿主血液中发生转变、通过蚊媒的不同组织进而感染新的脊椎动物宿主时，会对不断变化的环境进行精细的适应。尽管这些连续转变过程存在内在的复杂性，但疟原虫在脊椎动物宿主群体中的传播仍然极其成功。
