Ansell B M
Clin Exp Rheumatol. 1992 May-Jun;10 Suppl 7:15-8.
Hypertrophic osteoarthropathy should be considered in any child who presents with a non-inflammatory synovitis of the knees, ankles and wrists and particularly if there is finger clubbing or soft tissue hypertrophy of the fingers. It is rare to get the typical facial appearances until after adolescence. Alteration in epiphyseal growth is associated with the periosteal reaction, as is change in the shape of the patella; whether this leads to premature osteoarthrosis is not yet certain. Secondary disease is common in cyanotic congenital heart disease, but its frequency appears to be decreasing with early treatment of such children. Chest infections are also better controlled so again it is less common, but does still occur, particularly in cystic fibrosis in the older age group who have intractable chest infections. It is seen but rarely in disorders such as inflammatory bowel disease or pulmonary metastases, particularly from bone tumours.
对于任何出现膝关节、踝关节和腕关节非炎症性滑膜炎的儿童,尤其是伴有手指杵状指或手指软组织肥大的儿童,应考虑肥厚性骨关节病。直到青春期后才会出现典型的面部表现。骨骺生长改变与骨膜反应有关,髌骨形状改变也与之相关;这是否会导致过早的骨关节炎尚不确定。继发性疾病在青紫型先天性心脏病中很常见,但随着此类儿童的早期治疗,其发生率似乎在下降。胸部感染也得到了更好的控制,所以这种情况也不那么常见了,但仍然会发生,特别是在老年组患有难治性胸部感染的囊性纤维化患者中。在炎症性肠病或肺转移瘤等疾病中很少见到,特别是骨肿瘤的肺转移。