Division of Rheumatology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
Pediatr Rheumatol Online J. 2021 Jul 14;19(1):113. doi: 10.1186/s12969-021-00596-0.
Acro-osteolysis is a radiographic finding which refers to bone resorption of the distal phalanges. Acro-osteolysis is associated with various conditions and its presence should prompt the clinician to search for the underlying etiology. The aim of this review is to discuss disorders with which acro-osteolysis is associated and their distinguishing features, with a focus on the pediatric population.
A targeted literature review was performed using the term "acro-osteolysis" in combination with other key terms. The primary search results were supplemented using reference citations. Articles published prior to the year 2000 were included if they described additional associations not encountered in the more recent literature.
Genetic disorders (particularly primary hypertrophic osteoarthropathy and skeletal dysplasias) and rheumatic diseases (particularly psoriatic arthritis and systemic sclerosis) are the most frequently encountered conditions associated with acro-osteolysis in children. Hyperparathyroidism, neuropathy, local trauma and thermal injury, and spinal dysraphism should also be included in the differential diagnosis.
Although acro-osteolysis is uncommon, its presence should prompt the clinician to consider a differential diagnosis based on clinical and radiographic features.
杵状指（趾）骨溶解是一种放射学表现，指的是末节指（趾）骨的骨质吸收。杵状指（趾）骨溶解与多种疾病相关，其出现应促使临床医生寻找潜在病因。本文旨在讨论与杵状指（趾）骨溶解相关的疾病及其特征，重点关注儿科人群。
使用“杵状指（趾）骨溶解”一词，并结合其他关键词，进行有针对性的文献复习。主要检索结果通过参考文献进行补充。如果 2000 年以前发表的文章描述了在更近的文献中未遇到的其他关联，则将其纳入。
遗传疾病（特别是原发性肥大性骨关节病和骨骼发育不良）和风湿性疾病（特别是银屑病关节炎和系统性硬化症）是儿童中最常与杵状指（趾）骨溶解相关的疾病。甲状旁腺功能亢进、神经病变、局部创伤和热损伤以及脊髓发育不良也应纳入鉴别诊断。
尽管杵状指（趾）骨溶解并不常见，但它的出现应促使临床医生根据临床和影像学特征考虑鉴别诊断。
