Silveri F, Carlino G, Cervini C
Department of Rheumatology, University of Ancona, Italy.
Clin Exp Rheumatol. 1992 May-Jun;10 Suppl 7:61-6.
Various pathogenetic theories of hypertrophic osteoarthropathy (HOA) have been proposed (neurogenic, hormonal, artero-venous shunts, genetic theory), but none of them is able to satisfactorily explain the genesis of HOA. The hypothesis of a central role of the "endothelium/platelet unit" was recently discussed. Above all, the release of the platelet derived growth-factor (PDGF) contained in platelet granules is particularly interesting. In order to assess the microvascular involvement in HOA we set up a research project whose aims were to evaluate the morphology of the capillary network at the nailfold, the dynamic aspects of microcirculation and in vivo platelet function. Since this study is still in progress, for the time being we present only a few preliminary results.
关于肥大性骨关节病（HOA）已经提出了各种发病机制理论（神经源性、激素性、动静脉分流、遗传理论），但它们都无法令人满意地解释HOA的发病机制。最近讨论了“内皮/血小板单位”起核心作用的假说。最重要的是，血小板颗粒中所含的血小板衍生生长因子（PDGF）的释放特别令人关注。为了评估HOA中的微血管受累情况，我们开展了一个研究项目，其目的是评估甲襞处毛细血管网的形态、微循环的动态方面以及体内血小板功能。由于这项研究仍在进行中，目前我们仅展示一些初步结果。
