青少年呼吸功能与低出生体重、早产及宫内生长受限的关系

Respiratory function in adolescence in relation to low birth weight, preterm delivery, and intrauterine growth restriction.

作者信息

Lima Rosângela da C, Victora Cesar G, Menezes Ana Maria B, Barros Fernando C

机构信息

Post-Graduate Programme in Epidemiology, Universidade Federal de Pelotas, CP 464, Pelotas, 96001-970, Brazil.

出版信息

Chest. 2005 Oct;128(4):2400-7. doi: 10.1378/chest.128.4.2400.

DOI:10.1378/chest.128.4.2400

PMID:16236901

Abstract

OBJECTIVES

To study the associations between respiratory function in 18-year-old male subjects and birth weight, preterm delivery, and intrauterine growth restriction (IUGR).

METHODS

Population-based birth cohort. Subsamples of 118 male subjects with low birth weight (LBW) [< 2,500 g] and 236 male subjects with normal birth weight were examined at the age of 18 years.

RESULTS

In the crude analysis, subjects with LBW showed reductions in FEV1 and FVC of 0.166 L and 0.141 L, respectively, compared to those born weighing > or = 2,500 g. These differences were not significant after adjustment for confounding. When subjects with LBW were stratified into those with preterm delivery and those with IUGR, the latter presented a significant reduction in both FEV1 and FVC, when compared to the reference group. These differences also disappeared after adjustment for confounders. Preterm delivery per se was also not associated with poor lung function.

CONCLUSIONS

In this population, LBW was not associated with respiratory function in 18-year-old male subjects.

摘要

目的

研究18岁男性受试者的呼吸功能与出生体重、早产和宫内生长受限（IUGR）之间的关联。

方法

基于人群的出生队列研究。对118名低出生体重（LBW）[<2500克]的男性受试者和236名出生体重正常的男性受试者的子样本在18岁时进行了检查。

结果

在粗分析中，与出生体重≥2500克的受试者相比，低出生体重受试者的第一秒用力呼气容积（FEV1）和用力肺活量（FVC）分别降低了0.166升和0.141升。在对混杂因素进行调整后，这些差异不显著。当将低出生体重受试者分为早产组和宫内生长受限组时，与参照组相比，后者的FEV1和FVC均显著降低。在对混杂因素进行调整后，这些差异也消失了。早产本身也与肺功能差无关。