Department of Pediatrics, Clinical Sciences Lund, Lund University, Sweden.
Acta Paediatr. 2012 Jan;101(1):48-54. doi: 10.1111/j.1651-2227.2011.02435.x. Epub 2011 Aug 29.
To assess lung function at early school age in children delivered at very early gestation owing to intrauterine growth restriction and abnormal foetal blood flow (IUGR).
Spirometry was performed at median age 8.4 (range 6.5-10.7) years in 31 children born preterm with IUGR (PT-IUGR) with a median (range) birth weight (BW) of 650 (395-976) g and median (range) gestational age 27 (24-29) weeks. Control groups were matched for gender and age and had BW appropriate for gestational age (AGA); 31 children born preterm (PT-AGA) with BW of 1010 (660-1790) g matched for gestational age at birth, and 31 children born at term (T-AGA) with BW of 3530 (3000-4390) g.
The PT-IUGR group had lower mean (SD) values of z-scores for FEV(1), FEV(1)/FVC and forced mid-expiratory flow rate (FEF(25-75%)) compared to the T-AGA group, p = 0.003, p = 0.032 and p < 0.001, respectively, but did not differ from the PT-AGA group. PT-IUGR children delivered at ≥26 gestational weeks (GW) had lower FEF(25-75%) than PT-AGA children of corresponding GA, p = 0.014.
Lung function was reduced in the PT-IUGR group at early school age compared to controls born at term. The influence of IUGR on later lung function was only apparent in children born preterm after 26 GW.
评估因宫内生长受限和胎儿血流异常（IUGR）而早产的婴儿在早期学龄期的肺功能。
对 31 名患有 IUGR（PT-IUGR）的早产儿进行了肺功能测试，他们的中位年龄为 8.4 岁（范围为 6.5-10.7 岁），出生时的体重中位数（范围）为 650（395-976）克，中位（范围）胎龄为 27（24-29）周。对照组按性别和年龄匹配，出生体重适合胎龄（AGA）；31 名出生时体重为 1010（660-1790）克的早产儿（PT-AGA）与出生时胎龄相匹配，31 名足月出生（T-AGA）的儿童体重为 3530（3000-4390）克。
PT-IUGR 组的 FEV1、FEV1/FVC 和用力中呼气流速（FEF（25-75%））的 z 分数均值（SD）值均低于 T-AGA 组，p=0.003、p=0.032 和 p<0.001，分别，但与 PT-AGA 组无差异。孕 26 周（GW）以上分娩的 PT-IUGR 儿童的 FEF（25-75%）低于相应 GA 的 PT-AGA 儿童，p=0.014。
与足月出生的对照组相比，PT-IUGR 组在早期学龄期的肺功能较低。IUGR 对早产儿肺功能的影响仅在孕 26 周后出生的儿童中明显。
