Gill Namita, Nally Joseph V, Fatica Richard A
Department of General Internal Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA.
Chest. 2005 Oct;128(4):2847-63. doi: 10.1378/chest.128.4.2847.
Acute tubular necrosis (ATN) is a form of acute renal failure (ARF) that is common in hospitalized patients. In critical care units, it accounts for about 76% of cases of ARF. Despite the introduction of hemodialysis > 30 years ago, the mortality rates from ATN in hospitalized and ICU patients are about 37.1% and 78.6%, respectively. The purpose of this review is to discuss briefly the cause, diagnosis, and epidemiology of ARF, and to review in depth the clinical trials performed to date that have examined the influence of growth factors, hormones, antioxidants, diuretics, and dialysis. In particular, the role of the dialysis modality, dialyzer characteristics, and dosing strategies are discussed.
急性肾小管坏死（ATN）是急性肾衰竭（ARF）的一种形式，在住院患者中很常见。在重症监护病房，它约占ARF病例的76%。尽管30多年前就引入了血液透析，但住院患者和ICU患者中ATN的死亡率分别约为37.1%和78.6%。本综述的目的是简要讨论ARF的病因、诊断和流行病学，并深入回顾迄今为止进行的研究生长因子、激素、抗氧化剂、利尿剂和透析影响的临床试验。特别讨论了透析方式、透析器特性和给药策略的作用。
