N6-甲基腺嘌呤RNA甲基化表观遗传修饰与肾脏疾病

Luan Junjun, Kopp Jeffrey B, Zhou Hua

Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.

Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Bethesda, Maryland, USA.

Kidney Int Rep. 2022 Oct 17;8(1):36-50. doi: 10.1016/j.ekir.2022.10.009. eCollection 2023 Jan.

RNA methylation modification is a rapidly developing field in epigenetics. N6-methyladensine (mA) is the most common internal modification in eukaryotic mRNA. mA group regulates RNA splicing, stability, translocation, and translation. Enzymes catalyzing this process were termed as writers, erasers, and readers. Recent studies have focused on exploring the role of RNA methylation in human diseases. RNA methylation modifications, particularly mA, play important roles in the pathogenesis of kidney diseases. In this review, we provide a brief description of mA and summarize the impact of mA on acute and chronic kidney disease (CKD) and possible future study directions for this research.

RNA甲基化修饰是表观遗传学中一个快速发展的领域。N6-甲基腺嘌呤（m⁶A）是真核生物mRNA中最常见的内部修饰。m⁶A基团调节RNA剪接、稳定性、转运和翻译。催化这一过程的酶被称为“书写者”“擦除者”和“阅读者”。最近的研究集中在探索RNA甲基化在人类疾病中的作用。RNA甲基化修饰，尤其是m⁶A，在肾脏疾病的发病机制中起重要作用。在本综述中，我们简要描述了m⁶A，并总结了m⁶A对急性和慢性肾脏病（CKD）的影响以及该研究未来可能的方向。